Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 79050..79693 Replicon plasmid A
Accession NZ_CP010201
Organism Escherichia coli strain M10

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag RG59_RS25440 Protein ID WP_001044768.1
Coordinates 79050..79466 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag RG59_RS25445 Protein ID WP_001261287.1
Coordinates 79463..79693 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG59_RS25415 74491..75588 - 1098 WP_077898583.1 choloylglycine hydrolase family protein -
RG59_RS25420 75631..75849 - 219 WP_001292878.1 hypothetical protein -
RG59_RS25425 75998..76807 + 810 Protein_94 (S)-acetoin forming diacetyl reductase -
RG59_RS25435 77659..78888 + 1230 WP_072135265.1 IS66-like element accessory protein TnpA -
RG59_RS25440 79050..79466 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
RG59_RS25445 79463..79693 - 231 WP_001261287.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
RG59_RS26290 79671..79808 - 138 WP_077248527.1 toxin-antitoxin system, antitoxin component, AbrB family protein -
RG59_RS25460 79878..80320 - 443 Protein_99 transposase -
RG59_RS26295 80380..80621 + 242 Protein_100 hypothetical protein -
RG59_RS25470 80904..81788 - 885 WP_000942222.1 helix-turn-helix domain-containing protein -
RG59_RS25475 82073..82903 + 831 WP_012565223.1 helix-turn-helix domain-containing protein -
RG59_RS25480 82948..83766 - 819 WP_072135267.1 EAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - faeC / faeD / faeE / faeF / faeH / faeI 1..116581 116581


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T51354 WP_001044768.1 NZ_CP010201:c79466-79050 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

>T51354 NZ_CP010201:c79466-79050 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT51354 WP_001261287.1 NZ_CP010201:c79693-79463 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT51354 NZ_CP010201:c79693-79463 [Escherichia coli]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References