Detailed information of TA system TA051313

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4057485..4058283
• Replicon: chromosome
• Accession: NZ_CP010196
• Organism: Escherichia coli strain M9

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: RG58_RS21255
• Protein ID: WP_021573868.1
• Coordinates: 4057906..4058283 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: RG58_RS21250
• Protein ID: WP_073519787.1
• Coordinates: 4057485..4057859 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RG58_RS21205	4053458..4053910	+	453	WP_000682723.1	hypothetical protein	-
RG58_RS21210	4054028..4054261	+	234	WP_001213776.1	DUF905 family protein	-
RG58_RS21220	4054361..4055173	+	813	Protein_3839	DUF945 domain-containing protein	-
RG58_RS21230	4055522..4055995	+	474	WP_001313575.1	antirestriction protein	-
RG58_RS21235	4056011..4056487	+	477	WP_001186193.1	RadC family protein	-
RG58_RS21240	4056550..4056772	+	223	Protein_3842	DUF987 domain-containing protein	-
RG58_RS21245	4056791..4057435	+	645	WP_073519465.1	antitoxin of toxin-antitoxin stability system	-
RG58_RS21250	4057485..4057859	+	375	WP_073519787.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
RG58_RS21255	4057906..4058283	+	378	WP_021573868.1	TA system toxin CbtA family protein	Toxin
RG58_RS21260	4058280..4058772	+	493	Protein_3846	hypothetical protein	-
RG58_RS21270	4058851..4059839	-	989	Protein_3847	IS630 family transposase	-
RG58_RS21280	4060011..4061580	-	1570	Protein_3848	IS66 family transposase	-
RG58_RS21285	4061611..4061961	-	351	WP_000624707.1	IS66 family insertion sequence element accessory protein TnpB	-
RG58_RS21290	4061958..4062249	-	292	Protein_3850	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14299.33 Da
• Isoelectric Point: 6.8531

>T51313 WP_021573868.1 NZ_CP010196:4057906-4058283 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILLTRRATGLMTRSNYRMVNDIIRGEHSEAKR

Nucleotide

• Length: 378 bp

>T51313 NZ_CP010196:4057906-4058283 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCACGTTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACTCTGAATGACACACCATTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATTCTCCTGACCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13880.67 Da
• Isoelectric Point: 6.3118

>AT51313 WP_073519787.1 NZ_CP010196:4057485-4057859 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGRFRDADAYHLDQAFPLLMKQLKLMLTSG
ELNPCHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTLAPATTS

Nucleotide

• Length: 375 bp

>AT51313 NZ_CP010196:4057485-4057859 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCAGTATCAGAGGCCGGT
TCAGGGACGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGCGGT
GAACTGAATCCCTGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCTTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACTGGCACCCGCAACCACTTCATAA