Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 38917..39476 Replicon plasmid A
Accession NZ_CP010192
Organism Escherichia coli strain M8

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag RG57_RS25260 Protein ID WP_000421276.1
Coordinates 38917..39192 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag RG57_RS25265 Protein ID WP_001307030.1
Coordinates 39192..39476 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG57_RS26965 34342..34563 + 222 WP_024179415.1 hypothetical protein -
RG57_RS27815 34777..34869 - 93 Protein_34 transposase -
RG57_RS25215 35117..35323 + 207 Protein_35 alpha/beta hydrolase -
RG57_RS26970 35570..35933 + 364 Protein_36 helix-turn-helix domain containing protein -
RG57_RS27445 35937..36149 + 213 Protein_37 IS21 family transposase -
RG57_RS25230 36156..36524 - 369 WP_032246119.1 hypothetical protein -
RG57_RS25235 37425..37532 - 108 Protein_39 IS3 family transposase -
RG57_RS25240 37535..38034 - 500 Protein_40 transposase -
RG57_RS25245 38075..38266 + 192 Protein_41 recombinase family protein -
RG57_RS25255 38529..38810 - 282 WP_073535368.1 hypothetical protein -
RG57_RS25260 38917..39192 - 276 WP_000421276.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RG57_RS25265 39192..39476 - 285 WP_001307030.1 ribbon-helix-helix protein, CopG family Antitoxin
RG57_RS25270 39713..39838 - 126 Protein_45 IS66 family insertion sequence element accessory protein TnpB -
RG57_RS25275 39835..40269 - 435 WP_073535316.1 transposase -
RG57_RS26980 40839..41251 - 413 Protein_47 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..162720 162720
- inside IScluster/Tn - - 33007..40269 7262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10807.48 Da        Isoelectric Point: 9.6556

>T51291 WP_000421276.1 NZ_CP010192:c39192-38917 [Escherichia coli]
MELKWTSKALSDVARLFDFLVLASKPAAARTVQSLTQTPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNDQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T51291 NZ_CP010192:c39192-38917 [Escherichia coli]
ATGGAACTGAAATGGACCAGTAAGGCGCTTTCTGATGTGGCGCGGTTATTTGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGACACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGACCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10500.93 Da        Isoelectric Point: 5.5882

>AT51291 WP_001307030.1 NZ_CP010192:c39476-39192 [Escherichia coli]
MQMKNNTSHETKVITAHVPLLMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVSSGQVIDHVAVQAW
ADSLGTDNPLPVPR

Download         Length: 285 bp

>AT51291 NZ_CP010192:c39476-39192 [Escherichia coli]
ATGCAAATGAAAAACAATACCTCACATGAAACAAAAGTAATTACCGCGCATGTGCCATTACTTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGGCTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAAG
AACGTAATCGACTGACGCTGGAAGCCCTGGACGATGTGTCATCCGGACAGGTTATCGACCATGTAGCTGTTCAGGCCTGG
GCGGACAGCCTCGGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References