Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3215188..3216022 | Replicon | chromosome |
| Accession | NZ_CP010186 | ||
| Organism | Escherichia coli strain M6 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | RG56_RS16810 | Protein ID | WP_073519464.1 |
| Coordinates | 3215645..3216022 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | D2TSS6 |
| Locus tag | RG56_RS16805 | Protein ID | WP_012908802.1 |
| Coordinates | 3215188..3215556 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RG56_RS16775 | 3212085..3212903 | + | 819 | WP_061892566.1 | DUF945 domain-containing protein | - |
| RG56_RS16785 | 3213220..3213699 | + | 480 | WP_061892567.1 | antirestriction protein | - |
| RG56_RS16790 | 3213715..3214191 | + | 477 | WP_041124171.1 | RadC family protein | - |
| RG56_RS16795 | 3214254..3214475 | + | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| RG56_RS16800 | 3214494..3215138 | + | 645 | WP_073519465.1 | antitoxin of toxin-antitoxin stability system | - |
| RG56_RS16805 | 3215188..3215556 | + | 369 | WP_012908802.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| RG56_RS16810 | 3215645..3216022 | + | 378 | WP_073519464.1 | TA system toxin CbtA family protein | Toxin |
| RG56_RS28830 | 3216019..3216189 | + | 171 | Protein_3051 | hypothetical protein | - |
| RG56_RS28835 | 3216244..3216441 | + | 198 | WP_089560254.1 | DUF957 domain-containing protein | - |
| RG56_RS16820 | 3216526..3217086 | + | 561 | Protein_3053 | DUF4942 domain-containing protein | - |
| RG56_RS16825 | 3217454..3217990 | - | 537 | WP_000942795.1 | GspM family type II secretion system protein YghD | - |
| RG56_RS16830 | 3217992..3219170 | - | 1179 | WP_000094962.1 | type II secretion system protein GspL | - |
| RG56_RS16835 | 3219167..3220144 | - | 978 | WP_000633238.1 | type II secretion system minor pseudopilin GspK | - |
| RG56_RS16840 | 3220147..3220746 | - | 600 | WP_001255040.1 | type II secretion system minor pseudopilin GspJ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC | 3181131..3304144 | 123013 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14168.19 Da Isoelectric Point: 7.7294
>T51254 WP_073519464.1 NZ_CP010186:3215645-3216022 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T51254 NZ_CP010186:3215645-3216022 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAACAGCATATTG
AGGCGGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCTCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATCGATATCCTCCGGGCACGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAACAGCATATTG
AGGCGGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCTCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATCGATATCCTCCGGGCACGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13829.62 Da Isoelectric Point: 6.9465
>AT51254 WP_012908802.1 NZ_CP010186:3215188-3215556 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLGSCGYVYLAVYPTSETKK
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLGSCGYVYLAVYPTSETKK
Download Length: 369 bp
>AT51254 NZ_CP010186:3215188-3215556 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGGGACGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGGGACGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|