Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3512245..3512870 Replicon chromosome
Accession NZ_CP010183
Organism Escherichia coli strain M3

Toxin (Protein)


Gene name vapC Uniprot ID A0A2J1DF47
Locus tag RG55_RS18370 Protein ID WP_000911331.1
Coordinates 3512472..3512870 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag RG55_RS18365 Protein ID WP_000450524.1
Coordinates 3512245..3512472 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG55_RS18335 3508048..3508518 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
RG55_RS18340 3508518..3509090 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
RG55_RS18345 3509236..3510114 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
RG55_RS18350 3510131..3511165 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
RG55_RS18360 3511378..3512091 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
RG55_RS18365 3512245..3512472 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
RG55_RS18370 3512472..3512870 + 399 WP_000911331.1 tRNA(fMet)-specific endonuclease VapC Toxin
RG55_RS18375 3513017..3513880 + 864 WP_001267507.1 neutral zinc metallopeptidase -
RG55_RS18380 3513895..3515910 + 2016 WP_001543081.1 tRNA cytosine(34) acetyltransferase TmcA -
RG55_RS18385 3515984..3516682 + 699 WP_000679812.1 esterase -
RG55_RS18390 3516792..3516992 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14862.19 Da        Isoelectric Point: 9.2216

>T51223 WP_000911331.1 NZ_CP010183:3512472-3512870 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLVELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T51223 NZ_CP010183:3512472-3512870 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGGTGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTAACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT51223 WP_000450524.1 NZ_CP010183:3512245-3512472 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT51223 NZ_CP010183:3512245-3512472 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J1DF47

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References