Detailed information of TA system TA051206

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3284053..3284851
• Replicon: chromosome
• Accession: NZ_CP010180
• Organism: Escherichia coli strain M1

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: RG54_RS17185
• Protein ID: WP_000854902.1
• Coordinates: 3284053..3284430 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A093DMQ4
• Locus tag: RG54_RS17190
• Protein ID: WP_001280952.1
• Coordinates: 3284477..3284851 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RG54_RS17160	3280083..3281621	-	1539	WP_001187170.1	lysine decarboxylation/transport transcriptional activator CadC	-
RG54_RS17170	3282432..3283274	-	843	WP_073520689.1	DUF4942 domain-containing protein	-
RG54_RS17175	3283359..3283556	-	198	WP_073520690.1	DUF957 domain-containing protein	-
RG54_RS17180	3283568..3284056	-	489	WP_000779175.1	hypothetical protein	-
RG54_RS17185	3284053..3284430	-	378	WP_000854902.1	TA system toxin CbtA family protein	Toxin
RG54_RS17190	3284477..3284851	-	375	WP_001280952.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
RG54_RS17200	3285014..3285235	-	222	WP_000692311.1	DUF987 domain-containing protein	-
RG54_RS17205	3285298..3285774	-	477	WP_001186726.1	RadC family protein	-
RG54_RS17210	3285790..3286275	-	486	WP_000849591.1	antirestriction protein	-
RG54_RS17215	3286330..3287148	-	819	WP_001234620.1	DUF945 domain-containing protein	-
RG54_RS17220	3287207..3288778	-	1572	WP_073520623.1	IS66 family transposase	-
RG54_RS17225	3288798..3289145	-	348	WP_000624622.1	IS66 family insertion sequence element accessory protein TnpB	-
RG54_RS17230	3289145..3289792	-	648	WP_077897823.1	IS66 family insertion sequence hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3248950..3286275	37325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-118)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14307.29 Da
• Isoelectric Point: 7.2922

>T51206 WP_000854902.1 NZ_CP010180:c3284430-3284053 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
NACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Nucleotide

• Length: 378 bp

>T51206 NZ_CP010180:c3284430-3284053 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AATGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAAGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13719.50 Da
• Isoelectric Point: 6.6249

>AT51206 WP_001280952.1 NZ_CP010180:c3284851-3284477 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS

Nucleotide

• Length: 375 bp

>AT51206 NZ_CP010180:c3284851-3284477 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA

Structures

Antitoxin

• AlphaFold DB: A0A093DMQ4