Detailed information of TA system TA051080

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 485072..485870
• Replicon: chromosome
• Accession: NZ_CP010172
• Organism: Escherichia coli strain H8

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A1X1M0U2
• Locus tag: RG50_RS02565
• Protein ID: WP_000854919.1
• Coordinates: 485072..485449 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: RG50_RS02570
• Protein ID: WP_061090819.1
• Coordinates: 485496..485870 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RG50_RS02525	480277..481383	+	1107	WP_001353974.1	N-acetylneuraminate epimerase	-
RG50_RS02530	481448..482428	+	981	WP_001295601.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
RG50_RS02535	482436..483086	-	651	WP_001037966.1	HNH endonuclease	-
RG50_RS28995	484139..484285	-	147	WP_001290177.1	hypothetical protein	-
RG50_RS02555	484370..484567	-	198	WP_001327226.1	DUF957 domain-containing protein	-
RG50_RS02560	484587..485075	-	489	WP_061090820.1	hypothetical protein	-
RG50_RS02565	485072..485449	-	378	WP_000854919.1	TA system toxin CbtA family protein	Toxin
RG50_RS02570	485496..485870	-	375	WP_061090819.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
RG50_RS02580	486033..486254	-	222	WP_000692323.1	DUF987 domain-containing protein	-
RG50_RS02585	486317..486793	-	477	WP_001186771.1	RadC family protein	-
RG50_RS02590	486809..487288	-	480	WP_000860076.1	antirestriction protein	-
RG50_RS02595	487370..488188	-	819	WP_001234688.1	DUF945 domain-containing protein	-
RG50_RS02600	488374..489258	-	885	WP_000010380.1	50S ribosome-binding GTPase	-
RG50_RS02605	489359..490582	+	1224	WP_061090817.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14037.97 Da
• Isoelectric Point: 7.9086

>T51080 WP_000854919.1 NZ_CP010172:c485449-485072 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ

Nucleotide

• Length: 378 bp

>T51080 NZ_CP010172:c485449-485072 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGTCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13698.52 Da
• Isoelectric Point: 6.4757

>AT51080 WP_061090819.1 NZ_CP010172:c485870-485496 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPAITS

Nucleotide

• Length: 375 bp

>AT51080 NZ_CP010172:c485870-485496 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAATCACCTCATAA

Structures

Toxin

• AlphaFold DB: A0A1X1M0U2