Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 24254..24776 Replicon plasmid A
Accession NZ_CP010168
Organism Escherichia coli strain H3

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag RG46_RS24115 Protein ID WP_000220561.1
Coordinates 24254..24535 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag RG46_RS24120 Protein ID WP_000121743.1
Coordinates 24525..24776 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG46_RS24085 19730..19966 - 237 Protein_24 hypothetical protein -
RG46_RS24090 19987..20781 - 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
RG46_RS24095 20810..22240 - 1431 Protein_26 IS4-like element IS50R family transposase -
RG46_RS24100 22360..22548 + 189 WP_000957857.1 hypothetical protein -
RG46_RS24105 22558..23757 + 1200 WP_000948429.1 IS91 family transposase -
RG46_RS25215 23923..24015 + 93 Protein_29 IS6 family transposase -
RG46_RS24115 24254..24535 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RG46_RS24120 24525..24776 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
RG46_RS24135 26011..26850 + 840 WP_024129959.1 replication initiation protein -
RG46_RS24140 26871..27713 + 843 WP_000435064.1 replication initiation protein -
RG46_RS24145 27717..28163 + 447 WP_001074384.1 hypothetical protein -
RG46_RS24150 28231..28653 + 423 WP_179292036.1 DNA distortion polypeptide 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid tet(A) / floR / aph(3')-IIa / dfrA14 / ant(3'')-Ia / blaOXA-10 / cmlA1 / ARR-3 / qnrS1 - 1..48243 48243


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T51017 WP_000220561.1 NZ_CP010168:c24535-24254 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T51017 NZ_CP010168:c24535-24254 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT51017 WP_000121743.1 NZ_CP010168:c24776-24525 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT51017 NZ_CP010168:c24776-24525 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References