51002

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2675201..2675839 Replicon chromosome
Accession NZ_CP010167
Organism Escherichia coli strain H3

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag RG46_RS13760 Protein ID WP_000813794.1
Coordinates 2675201..2675377 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag RG46_RS13765 Protein ID WP_001270286.1
Coordinates 2675423..2675839 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG46_RS13740 2670820..2672034 - 1215 WP_001348055.1 BenE family transporter YdcO -
RG46_RS13745 2672087..2672623 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
RG46_RS13750 2672696..2674657 + 1962 WP_001593323.1 23S rRNA 5-hydroxycytidine C2501 synthase -
RG46_RS13755 2674749..2674979 - 231 WP_000494244.1 YncJ family protein -
RG46_RS13760 2675201..2675377 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
RG46_RS13765 2675423..2675839 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
RG46_RS13770 2675918..2677324 + 1407 WP_000760592.1 PLP-dependent aminotransferase family protein -
RG46_RS13775 2677569..2678714 + 1146 WP_000047456.1 ABC transporter substrate-binding protein -
RG46_RS13780 2678732..2679745 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
RG46_RS13785 2679746..2680687 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T51002 WP_000813794.1 NZ_CP010167:2675201-2675377 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T51002 NZ_CP010167:2675201-2675377 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT51002 WP_001270286.1 NZ_CP010167:2675423-2675839 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT51002 NZ_CP010167:2675423-2675839 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References