50959

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1509818..1510472 Replicon chromosome
Accession NZ_CP010160
Organism Escherichia coli strain H1

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag RG44_RS08145 Protein ID WP_000244777.1
Coordinates 1509818..1510225 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag RG44_RS08150 Protein ID WP_000354046.1
Coordinates 1510206..1510472 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG44_RS08125 1505775..1507508 - 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -
RG44_RS08130 1507514..1508224 - 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
RG44_RS08135 1508249..1509145 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
RG44_RS08140 1509257..1509778 + 522 WP_001055874.1 flavodoxin FldB -
RG44_RS08145 1509818..1510225 - 408 WP_000244777.1 toxin CptA Toxin
RG44_RS08150 1510206..1510472 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
RG44_RS08155 1510715..1511695 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
RG44_RS08160 1511891..1512550 - 660 WP_000250274.1 hemolysin III family protein -
RG44_RS08165 1512714..1513025 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
RG44_RS08170 1513070..1514503 + 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
RG44_RS08175 1514560..1515303 - 744 WP_033865725.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T50959 WP_000244777.1 NZ_CP010160:c1510225-1509818 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T50959 NZ_CP010160:c1510225-1509818 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT50959 WP_000354046.1 NZ_CP010160:c1510472-1510206 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT50959 NZ_CP010160:c1510472-1510206 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References