Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5091935..5092770 Replicon chromosome
Accession NZ_CP010157
Organism Escherichia coli strain D10

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag RG43_RS26860 Protein ID WP_057109034.1
Coordinates 5091935..5092312 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8S7S1S5
Locus tag RG43_RS26865 Protein ID WP_065793167.1
Coordinates 5092402..5092770 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG43_RS26830 5087017..5087622 + 606 WP_001318033.1 type II secretion system minor pseudopilin GspJ -
RG43_RS26835 5087619..5088596 + 978 WP_073506912.1 type II secretion system minor pseudopilin GspK -
RG43_RS26840 5088593..5089771 + 1179 WP_000097200.1 type II secretion system protein GspL -
RG43_RS26845 5089773..5090309 + 537 WP_000942807.1 GspM family type II secretion system protein YghD -
RG43_RS26850 5090589..5091431 - 843 WP_039004748.1 DUF4942 domain-containing protein -
RG43_RS29310 5091516..5091713 - 198 WP_023563519.1 DUF957 domain-containing protein -
RG43_RS29315 5091789..5091938 - 150 Protein_4786 hypothetical protein -
RG43_RS26860 5091935..5092312 - 378 WP_057109034.1 TA system toxin CbtA family protein Toxin
RG43_RS26865 5092402..5092770 - 369 WP_065793167.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
RG43_RS26875 5092933..5093154 - 222 WP_000692303.1 DUF987 domain-containing protein -
RG43_RS26880 5093217..5093693 - 477 WP_001186710.1 RadC family protein -
RG43_RS26885 5093709..5094188 - 480 WP_057109036.1 antirestriction protein -
RG43_RS29535 5094288..5094428 + 141 WP_000997937.1 hypothetical protein -
RG43_RS26895 5094454..5095272 - 819 WP_001175153.1 DUF945 domain-containing protein -
RG43_RS26900 5095362..5095595 - 234 WP_001278287.1 DUF905 family protein -
RG43_RS26905 5095601..5096278 - 678 WP_001097305.1 hypothetical protein -
RG43_RS26910 5096426..5097106 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM 5066443..5110113 43670


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13934.86 Da        Isoelectric Point: 6.8517

>T50940 WP_057109034.1 NZ_CP010157:c5092312-5091935 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

>T50940 NZ_CP010157:c5092312-5091935 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACCGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13555.50 Da        Isoelectric Point: 6.6249

>AT50940 WP_065793167.1 NZ_CP010157:c5092770-5092402 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT50940 NZ_CP010157:c5092770-5092402 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References