Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4929865..4930400 Replicon chromosome
Accession NZ_CP010157
Organism Escherichia coli strain D10

Toxin (Protein)


Gene name relE Uniprot ID Q3YTD6
Locus tag RG43_RS26020 Protein ID WP_000222766.1
Coordinates 4929865..4930152 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0VIP2
Locus tag RG43_RS26025 Protein ID WP_001132900.1
Coordinates 4930149..4930400 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG43_RS25995 4924946..4926994 + 2049 WP_000792543.1 TonB-dependent siderophore receptor IreA -
RG43_RS26000 4927174..4928338 - 1165 Protein_4631 IS256 family transposase -
RG43_RS28575 4928376..4929588 + 1213 Protein_4632 IS3 family transposase -
RG43_RS26020 4929865..4930152 - 288 WP_000222766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RG43_RS26025 4930149..4930400 - 252 WP_001132900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RG43_RS26040 4931364..4932221 - 858 WP_000130940.1 incFII family plasmid replication initiator RepA -
RG43_RS26045 4932214..4932288 - 75 WP_001365705.1 RepA leader peptide Tap -
RG43_RS26055 4932514..4932774 - 261 WP_073507066.1 replication regulatory protein RepA -
RG43_RS26060 4933013..4933586 - 574 Protein_4638 DUF2726 domain-containing protein -
RG43_RS26065 4933624..4933833 - 210 WP_001333231.1 hemolysin expression modulator Hha -
RG43_RS26070 4933879..4934340 - 462 WP_001233871.1 thermonuclease family protein -
RG43_RS26075 4934583..4934795 - 213 WP_012311405.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4914257..4957300 43043


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11147.23 Da        Isoelectric Point: 10.5832

>T50938 WP_000222766.1 NZ_CP010157:c4930152-4929865 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKTIQQQFVKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp

>T50938 NZ_CP010157:c4930152-4929865 [Escherichia coli]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCAGCAAAACTAAGAGGGCTAAAGGATTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9211.41 Da        Isoelectric Point: 4.0780

>AT50938 WP_001132900.1 NZ_CP010157:c4930400-4930149 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT50938 NZ_CP010157:c4930400-4930149 [Escherichia coli]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTAGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDZ2

Antitoxin

Source ID Structure
AlphaFold DB V0VIP2

References