Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 860341..861176 Replicon chromosome
Accession NZ_CP010157
Organism Escherichia coli strain D10

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag RG43_RS04485 Protein ID WP_057109034.1
Coordinates 860341..860718 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MK11
Locus tag RG43_RS04490 Protein ID WP_001285610.1
Coordinates 860808..861176 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG43_RS04455 855423..856028 + 606 WP_001318033.1 type II secretion system minor pseudopilin GspJ -
RG43_RS04460 856025..857002 + 978 WP_073506912.1 type II secretion system minor pseudopilin GspK -
RG43_RS04465 856999..858177 + 1179 WP_000097200.1 type II secretion system protein GspL -
RG43_RS04470 858179..858715 + 537 WP_000942807.1 GspM family type II secretion system protein YghD -
RG43_RS04475 858995..859837 - 843 WP_039004748.1 DUF4942 domain-containing protein -
RG43_RS28815 859922..860119 - 198 WP_023563519.1 DUF957 domain-containing protein -
RG43_RS28820 860195..860344 - 150 Protein_812 hypothetical protein -
RG43_RS04485 860341..860718 - 378 WP_057109034.1 TA system toxin CbtA family protein Toxin
RG43_RS04490 860808..861176 - 369 WP_001285610.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
RG43_RS04495 861250..861471 - 222 Protein_815 DUF987 domain-containing protein -
RG43_RS04500 861558..862034 - 477 WP_057109035.1 RadC family protein -
RG43_RS04505 862050..862529 - 480 WP_057109036.1 antirestriction protein -
RG43_RS29410 862629..862769 + 141 WP_000997937.1 hypothetical protein -
RG43_RS04515 862795..863613 - 819 WP_001175153.1 DUF945 domain-containing protein -
RG43_RS04520 863703..863936 - 234 WP_073506913.1 DUF905 family protein -
RG43_RS04525 863942..864619 - 678 WP_073506914.1 hypothetical protein -
RG43_RS04530 864738..865622 - 885 WP_000010392.1 50S ribosome-binding GTPase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element sul2 / tet(B) gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / papI / papB / papA / papH / papC / papD / papJ / papK / papE / papF / papG 800638..916136 115498


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(19-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13934.86 Da        Isoelectric Point: 6.8517

>T50916 WP_057109034.1 NZ_CP010157:c860718-860341 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

>T50916 NZ_CP010157:c860718-860341 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACCGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13606.39 Da        Isoelectric Point: 6.0618

>AT50916 WP_001285610.1 NZ_CP010157:c861176-860808 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT50916 NZ_CP010157:c861176-860808 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGTGCCCGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCAGACCGTGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References