Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2049037..2049838 Replicon chromosome
Accession NZ_CP010151
Organism Escherichia coli strain D8

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag RG41_RS10625 Protein ID WP_000854739.1
Coordinates 2049037..2049417 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag RG41_RS10630 Protein ID WP_001285482.1
Coordinates 2049464..2049838 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG41_RS10590 2044629..2045183 - 555 WP_001001921.1 molecular chaperone YcdY -
RG41_RS10595 2045207..2045944 - 738 WP_000283664.1 zinc-binding phosphatase -
RG41_RS10600 2045999..2046937 - 939 WP_000351277.1 glyoxylate/hydroxypyruvate reductase GhrA -
RG41_RS10610 2047423..2048250 - 828 WP_001518536.1 DUF4942 domain-containing protein -
RG41_RS10615 2048335..2048532 - 198 WP_000772027.1 DUF957 domain-containing protein -
RG41_RS10620 2048552..2049040 - 489 WP_001518535.1 hypothetical protein -
RG41_RS10625 2049037..2049417 - 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
RG41_RS10630 2049464..2049838 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
RG41_RS10635 2049888..2050532 - 645 WP_000086759.1 hypothetical protein -
RG41_RS10640 2050551..2050772 - 222 WP_000692315.1 DUF987 domain-containing protein -
RG41_RS10645 2050835..2051311 - 477 WP_001313574.1 RadC family protein -
RG41_RS10650 2051327..2051800 - 474 WP_001313575.1 antirestriction protein -
RG41_RS10655 2051894..2052139 - 246 WP_001164966.1 hypothetical protein -
RG41_RS10660 2052139..2052957 - 819 WP_001560884.1 DUF945 domain-containing protein -
RG41_RS27600 2053112..2053246 - 135 WP_032144430.1 DUF905 family protein -
RG41_RS10675 2053347..2053802 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T50866 WP_000854739.1 NZ_CP010151:c2049417-2049037 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T50866 NZ_CP010151:c2049417-2049037 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTTGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT50866 WP_001285482.1 NZ_CP010151:c2049838-2049464 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT50866 NZ_CP010151:c2049838-2049464 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCTTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References