Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1005453..1006284 Replicon chromosome
Accession NZ_CP010151
Organism Escherichia coli strain D8

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag RG41_RS04925 Protein ID WP_000854814.1
Coordinates 1005453..1005827 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A366YXM1
Locus tag RG41_RS04930 Protein ID WP_001518724.1
Coordinates 1005916..1006284 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG41_RS04890 1000849..1002015 + 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
RG41_RS04895 1002134..1002607 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
RG41_RS04900 1002805..1003863 + 1059 WP_001200894.1 FUSC family protein -
RG41_RS04905 1004035..1004364 + 330 WP_000450409.1 DUF496 family protein -
RG41_RS04910 1004465..1004647 - 183 WP_001016348.1 hypothetical protein -
RG41_RS26820 1004701..1004847 + 147 Protein_895 transposase domain-containing protein -
RG41_RS27445 1005136..1005249 - 114 WP_001161660.1 DUF957 domain-containing protein -
RG41_RS04920 1005262..1005456 - 195 WP_000988601.1 hypothetical protein -
RG41_RS04925 1005453..1005827 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
RG41_RS04930 1005916..1006284 - 369 WP_001518724.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
RG41_RS04935 1006358..1006579 - 222 WP_000692323.1 DUF987 domain-containing protein -
RG41_RS04940 1006642..1007118 - 477 WP_001186773.1 RadC family protein -
RG41_RS04945 1007134..1007607 - 474 WP_000855075.1 antirestriction protein -
RG41_RS04955 1007870..1008691 - 822 WP_074434897.1 DUF945 domain-containing protein -
RG41_RS04960 1008912..1009322 - 411 WP_000846705.1 hypothetical protein -
RG41_RS04965 1009338..1009991 - 654 WP_001535423.1 hypothetical protein -
RG41_RS04975 1010084..1011261 + 1178 WP_152895938.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T50855 WP_000854814.1 NZ_CP010151:c1005827-1005453 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T50855 NZ_CP010151:c1005827-1005453 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13441.24 Da        Isoelectric Point: 4.7594

>AT50855 WP_001518724.1 NZ_CP010151:c1006284-1005916 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLSSDADAYPLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLACEADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT50855 NZ_CP010151:c1006284-1005916 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
CCAGCGATGCAGATGCGTACCCCCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCAATCAGCATACCGTCACGCTGTATGCGAAGGGGCTGGCCTGTGAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A366YXM1

References