Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1409333..1410164 Replicon chromosome
Accession NZ_CP010145
Organism Escherichia coli strain D5

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag RG38_RS07550 Protein ID WP_000854814.1
Coordinates 1409790..1410164 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag RG38_RS07545 Protein ID WP_001285585.1
Coordinates 1409333..1409701 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG38_RS07510 1406237..1406692 + 456 WP_000581504.1 hypothetical protein -
RG38_RS07515 1406771..1407004 + 234 WP_001119729.1 DUF905 family protein -
RG38_RS07525 1407104..1407922 + 819 WP_001234629.1 DUF945 domain-containing protein -
RG38_RS07530 1408004..1408483 + 480 WP_000860087.1 antirestriction protein -
RG38_RS07535 1408499..1408975 + 477 WP_001186726.1 RadC family protein -
RG38_RS07540 1409038..1409259 + 222 WP_000692323.1 DUF987 domain-containing protein -
RG38_RS07545 1409333..1409701 + 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
RG38_RS07550 1409790..1410164 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
RG38_RS07555 1410161..1410355 + 195 WP_000988600.1 hypothetical protein -
RG38_RS27370 1410368..1410481 + 114 WP_001161660.1 DUF957 domain-containing protein -
RG38_RS26810 1410770..1410898 - 129 Protein_1348 transposase domain-containing protein -
RG38_RS07565 1410970..1411152 + 183 WP_001016348.1 hypothetical protein -
RG38_RS07570 1411253..1411582 - 330 WP_000450409.1 DUF496 family protein -
RG38_RS07575 1411754..1412812 - 1059 WP_073511509.1 FUSC family protein -
RG38_RS07580 1413010..1413483 - 474 WP_001105408.1 DNA gyrase inhibitor SbmC -
RG38_RS07585 1413602..1414768 - 1167 WP_073511510.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T50777 WP_000854814.1 NZ_CP010145:1409790-1410164 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T50777 NZ_CP010145:1409790-1410164 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT50777 WP_001285585.1 NZ_CP010145:1409333-1409701 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT50777 NZ_CP010145:1409333-1409701 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References