Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4236649..4237463 Replicon chromosome
Accession NZ_CP010137
Organism Escherichia coli strain D2

Toxin (Protein)


Gene name yjhX Uniprot ID A0A6C9SL90
Locus tag RG35_RS22215 Protein ID WP_001054375.1
Coordinates 4236649..4236906 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag RG35_RS22220 Protein ID WP_001309181.1
Coordinates 4236918..4237463 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG35_RS22190 4231937..4233043 + 1107 WP_001299704.1 N-acetylneuraminate epimerase -
RG35_RS22195 4233108..4234088 + 981 WP_000991455.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
RG35_RS22205 4234671..4235911 - 1241 Protein_3992 helicase YjhR -
RG35_RS26665 4236027..4236272 + 246 Protein_3993 GNAT family N-acetyltransferase -
RG35_RS22215 4236649..4236906 + 258 WP_001054375.1 hypothetical protein Toxin
RG35_RS22220 4236918..4237463 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
RG35_RS22225 4237519..4238265 + 747 WP_000354252.1 class I SAM-dependent methyltransferase -
RG35_RS26175 4238434..4238652 + 219 Protein_3997 hypothetical protein -
RG35_RS27225 4238690..4238806 + 117 Protein_3998 VOC family protein -
RG35_RS22235 4239051..4240172 + 1122 WP_000010831.1 M42 family metallopeptidase -
RG35_RS22240 4240169..4240447 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
RG35_RS22245 4240459..4241772 + 1314 WP_000460845.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4229256..4245687 16431


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9768.31 Da        Isoelectric Point: 11.0090

>T50690 WP_001054375.1 NZ_CP010137:4236649-4236906 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QFDNR

Download         Length: 258 bp

>T50690 NZ_CP010137:4236649-4236906 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGTTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19938.86 Da        Isoelectric Point: 6.3277

>AT50690 WP_001309181.1 NZ_CP010137:4236918-4237463 [Escherichia coli]
ITVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT50690 NZ_CP010137:4236918-4237463 [Escherichia coli]
ATAACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACTGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C9SL90

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References