Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1136845..1137499 Replicon chromosome
Accession NZ_CP010137
Organism Escherichia coli strain D2

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag RG35_RS05925 Protein ID WP_073544115.1
Coordinates 1137092..1137499 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag RG35_RS05920 Protein ID WP_000354046.1
Coordinates 1136845..1137111 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG35_RS05895 1132014..1132757 + 744 WP_000951948.1 SDR family oxidoreductase -
RG35_RS05900 1132814..1134247 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
RG35_RS05905 1134292..1134603 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
RG35_RS05910 1134767..1135426 + 660 WP_000250274.1 hemolysin III family protein -
RG35_RS05915 1135622..1136602 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
RG35_RS05920 1136845..1137111 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
RG35_RS05925 1137092..1137499 + 408 WP_073544115.1 protein YgfX Toxin
RG35_RS05930 1137539..1138060 - 522 WP_001055874.1 flavodoxin FldB -
RG35_RS05935 1138172..1139068 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
RG35_RS05940 1139093..1139803 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
RG35_RS05945 1139809..1141542 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16060.01 Da        Isoelectric Point: 11.5202

>T50673 WP_073544115.1 NZ_CP010137:1137092-1137499 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAVDSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T50673 NZ_CP010137:1137092-1137499 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGTCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT50673 WP_000354046.1 NZ_CP010137:1136845-1137111 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT50673 NZ_CP010137:1136845-1137111 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References