Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 474..1117 Replicon plasmid B
Accession NZ_CP010136
Organism Escherichia coli strain D1

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag RG34_RS27360 Protein ID WP_077897775.1
Coordinates 701..1117 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag RG34_RS27355 Protein ID WP_073514781.1
Coordinates 474..704 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG34_RS27355 474..704 + 231 WP_073514781.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
RG34_RS27360 701..1117 + 417 WP_077897775.1 type II toxin-antitoxin system VapC family toxin Toxin
RG34_RS27365 1213..2136 - 924 Protein_2 peptidase -
RG34_RS27370 2254..3324 + 1071 WP_073514782.1 IS481 family transposase -
RG34_RS27375 3660..4280 + 621 WP_073514783.1 T3SS effector NleG family protein -
RG34_RS27380 4455..4988 - 534 Protein_5 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - cif 1..55203 55203


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15154.63 Da        Isoelectric Point: 7.7809

>T50666 WP_077897775.1 NZ_CP010136:701-1117 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHITLVNAFCDRLDAILPWDRA
AVDITTDIKVALRTAGTPIGPNDTAIAGHAIAVGAILVTNNVREFERVPGLVLEDWVK

Download         Length: 417 bp

>T50666 NZ_CP010136:701-1117 [Escherichia coli]
GTGAATAAAACGTATATGCTTGATACCTGTATCTGTTCGTTCATCATGCGCGAACAGCCTGAAGCCGTACTGAAACGCCT
GGAGCAGGCGGTGCTGCGCGGCCATCGTATCGTGGTCTCGGCTATTACTTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCTTCCCCGCGTCACATTACTCTAGTCAACGCGTTCTGTGACCGACTCGATGCCATCCTGCCTTGGGATCGTGCT
GCAGTGGACATCACCACCGATATCAAGGTGGCACTGCGCACTGCCGGTACGCCGATCGGCCCAAACGACACAGCAATCGC
CGGTCATGCCATTGCCGTCGGTGCGATCCTGGTAACCAATAATGTGCGAGAATTTGAGAGGGTTCCCGGCCTGGTGCTGG
AAGACTGGGTTAAATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8881.02 Da        Isoelectric Point: 4.6437

>AT50666 WP_073514781.1 NZ_CP010136:474-704 [Escherichia coli]
MRTVSIFRNGNNRAIRLPRDLDFEGVSELEIIREGDSIILRPVRPTWSSFRELEKAAPDFMTEREDIVNDEGRFSL

Download         Length: 231 bp

>AT50666 NZ_CP010136:474-704 [Escherichia coli]
ATGCGAACAGTATCTATTTTCAGAAACGGCAATAACCGCGCTATCCGTCTGCCCCGCGATCTGGATTTTGAAGGGGTAAG
CGAGCTCGAAATCATCCGGGAAGGGGACAGCATCATTCTGCGCCCTGTCCGGCCGACCTGGAGCTCATTCCGGGAGCTCG
AAAAGGCCGCTCCGGACTTTATGACGGAGCGCGAGGACATTGTCAACGACGAAGGACGATTTAGCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References