Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3538093..3538711 Replicon chromosome
Accession NZ_CP010129
Organism Escherichia coli strain C9

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag RG31_RS18985 Protein ID WP_001291435.1
Coordinates 3538493..3538711 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag RG31_RS18980 Protein ID WP_073511080.1
Coordinates 3538093..3538467 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG31_RS18970 3533182..3534375 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
RG31_RS18975 3534398..3537547 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
RG31_RS18980 3538093..3538467 + 375 WP_073511080.1 Hha toxicity modulator TomB Antitoxin
RG31_RS18985 3538493..3538711 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
RG31_RS18990 3538883..3539434 + 552 WP_000102564.1 maltose O-acetyltransferase -
RG31_RS18995 3539550..3540020 + 471 WP_000136192.1 YlaC family protein -
RG31_RS19000 3540184..3541734 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
RG31_RS19005 3541776..3542129 - 354 WP_000878140.1 DUF1428 domain-containing protein -
RG31_RS19015 3542508..3542819 + 312 WP_000409911.1 MGMT family protein -
RG31_RS19020 3542850..3543422 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T50578 WP_001291435.1 NZ_CP010129:3538493-3538711 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T50578 NZ_CP010129:3538493-3538711 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14523.37 Da        Isoelectric Point: 4.7395

>AT50578 WP_073511080.1 NZ_CP010129:3538093-3538467 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCIVNATKENPASLSC

Download         Length: 375 bp

>AT50578 NZ_CP010129:3538093-3538467 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTATTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References