Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5196983..5197818 Replicon chromosome
Accession NZ_CP010122
Organism Escherichia coli strain C5

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag RG28_RS27495 Protein ID WP_000854735.1
Coordinates 5196983..5197360 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A168HAW2
Locus tag RG28_RS27500 Protein ID WP_061351926.1
Coordinates 5197450..5197818 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG28_RS27470 5193953..5194900 - 948 WP_012139193.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
RG28_RS27475 5194893..5195288 - 396 WP_000208385.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
RG28_RS27480 5195357..5196204 - 848 Protein_4976 DUF4942 domain-containing protein -
RG28_RS27485 5196289..5196486 - 198 WP_000839249.1 DUF957 domain-containing protein -
RG28_RS27490 5196498..5196986 - 489 WP_073521171.1 hypothetical protein -
RG28_RS27495 5196983..5197360 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
RG28_RS27500 5197450..5197818 - 369 WP_061351926.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
RG28_RS27505 5197868..5198512 - 645 WP_073521172.1 antitoxin of toxin-antitoxin stability system -
RG28_RS27510 5198531..5198752 - 222 WP_024216021.1 DUF987 domain-containing protein -
RG28_RS27515 5198821..5199297 - 477 WP_001685369.1 RadC family protein -
RG28_RS27520 5199313..5199789 - 477 WP_073521173.1 antirestriction protein -
RG28_RS27530 5199976..5200803 - 828 WP_061352014.1 DUF945 domain-containing protein -
RG28_RS27540 5200949..5201128 - 180 WP_061361860.1 DUF905 family protein -
RG28_RS27545 5201170..5201706 - 537 WP_047628209.1 DUF4234 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T50508 WP_000854735.1 NZ_CP010122:c5197360-5196983 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T50508 NZ_CP010122:c5197360-5196983 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13761.47 Da        Isoelectric Point: 5.9582

>AT50508 WP_061351926.1 NZ_CP010122:c5197818-5197450 [Escherichia coli]
VSDTLHETNYPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKR

Download         Length: 369 bp

>AT50508 NZ_CP010122:c5197818-5197450 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGCGCCCGTCTGGTACAGGAGGGCAATCAGTTGCATTACCTTGCAGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACCCGAAACGAAAAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A168HAW2

References