Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 5196983..5197818 | Replicon | chromosome |
| Accession | NZ_CP010122 | ||
| Organism | Escherichia coli strain C5 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | U9XMP3 |
| Locus tag | RG28_RS27495 | Protein ID | WP_000854735.1 |
| Coordinates | 5196983..5197360 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A168HAW2 |
| Locus tag | RG28_RS27500 | Protein ID | WP_061351926.1 |
| Coordinates | 5197450..5197818 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RG28_RS27470 | 5193953..5194900 | - | 948 | WP_012139193.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| RG28_RS27475 | 5194893..5195288 | - | 396 | WP_000208385.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
| RG28_RS27480 | 5195357..5196204 | - | 848 | Protein_4976 | DUF4942 domain-containing protein | - |
| RG28_RS27485 | 5196289..5196486 | - | 198 | WP_000839249.1 | DUF957 domain-containing protein | - |
| RG28_RS27490 | 5196498..5196986 | - | 489 | WP_073521171.1 | hypothetical protein | - |
| RG28_RS27495 | 5196983..5197360 | - | 378 | WP_000854735.1 | TA system toxin CbtA family protein | Toxin |
| RG28_RS27500 | 5197450..5197818 | - | 369 | WP_061351926.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| RG28_RS27505 | 5197868..5198512 | - | 645 | WP_073521172.1 | antitoxin of toxin-antitoxin stability system | - |
| RG28_RS27510 | 5198531..5198752 | - | 222 | WP_024216021.1 | DUF987 domain-containing protein | - |
| RG28_RS27515 | 5198821..5199297 | - | 477 | WP_001685369.1 | RadC family protein | - |
| RG28_RS27520 | 5199313..5199789 | - | 477 | WP_073521173.1 | antirestriction protein | - |
| RG28_RS27530 | 5199976..5200803 | - | 828 | WP_061352014.1 | DUF945 domain-containing protein | - |
| RG28_RS27540 | 5200949..5201128 | - | 180 | WP_061361860.1 | DUF905 family protein | - |
| RG28_RS27545 | 5201170..5201706 | - | 537 | WP_047628209.1 | DUF4234 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14061.07 Da Isoelectric Point: 8.2904
>T50508 WP_000854735.1 NZ_CP010122:c5197360-5196983 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T50508 NZ_CP010122:c5197360-5196983 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13761.47 Da Isoelectric Point: 5.9582
>AT50508 WP_061351926.1 NZ_CP010122:c5197818-5197450 [Escherichia coli]
VSDTLHETNYPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKR
VSDTLHETNYPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKR
Download Length: 369 bp
>AT50508 NZ_CP010122:c5197818-5197450 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGCGCCCGTCTGGTACAGGAGGGCAATCAGTTGCATTACCTTGCAGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACCCGAAACGAAAAGGTAA
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGCGCCCGTCTGGTACAGGAGGGCAATCAGTTGCATTACCTTGCAGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACCCGAAACGAAAAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | U9XMP3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A168HAW2 |