50507

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 5193953..5195288 Replicon chromosome
Accession NZ_CP010122
Organism Escherichia coli strain C5

Toxin (Protein)


Gene name sanaT Uniprot ID A7ZRI5
Locus tag RG28_RS27470 Protein ID WP_012139193.1
Coordinates 5193953..5194900 (-) Length 316 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A0Q1C5A3
Locus tag RG28_RS27475 Protein ID WP_000208385.1
Coordinates 5194893..5195288 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG28_RS27450 5189892..5191226 - 1335 WP_000092909.1 cadaverine/lysine antiporter -
RG28_RS27460 5191592..5193130 - 1539 WP_001187182.1 lysine decarboxylation/transport transcriptional activator CadC -
RG28_RS27470 5193953..5194900 - 948 WP_012139193.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
RG28_RS27475 5194893..5195288 - 396 WP_000208385.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
RG28_RS27480 5195357..5196204 - 848 Protein_4976 DUF4942 domain-containing protein -
RG28_RS27485 5196289..5196486 - 198 WP_000839249.1 DUF957 domain-containing protein -
RG28_RS27490 5196498..5196986 - 489 WP_073521171.1 hypothetical protein -
RG28_RS27495 5196983..5197360 - 378 WP_000854735.1 TA system toxin CbtA family protein -
RG28_RS27500 5197450..5197818 - 369 WP_061351926.1 type IV toxin-antitoxin system YeeU family antitoxin -
RG28_RS27505 5197868..5198512 - 645 WP_073521172.1 antitoxin of toxin-antitoxin stability system -
RG28_RS27510 5198531..5198752 - 222 WP_024216021.1 DUF987 domain-containing protein -
RG28_RS27515 5198821..5199297 - 477 WP_001685369.1 RadC family protein -
RG28_RS27520 5199313..5199789 - 477 WP_073521173.1 antirestriction protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-302)

Antitoxin

Protein of unknown function DUF6088

(10-129)


Sequences

Toxin        


Download         Length: 316 a.a.        Molecular weight: 36147.49 Da        Isoelectric Point: 5.7165

>T50507 WP_012139193.1 NZ_CP010122:c5194900-5193953 [Escherichia coli]
MPELTSLFPDVANALDIESVAIVEKDYFVVNLLKLLKEIKPETHTLVFAGGTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVLHNSDIFSLDNENARITRDEYRYNEIPVRYPQAFAQAPCLRPFIKLELMETTLLEHPESR
DIYSLVTEVTGNGTPVTAFPCATILSTQAEKLISMMRRTAILLRNPEQQDDESLVRHIYDNYCIVREKGVNVPVLKNFVQ
VCIQQDIERYGNQHPQFCNSPVDELKKGLDALRDDPVHKLRFQRFVKPMVFGNTQIDWEEAYSCFRQTALSVLTS

Download         Length: 948 bp

>T50507 NZ_CP010122:c5194900-5193953 [Escherichia coli]
ATGCCTGAATTAACATCATTATTTCCTGACGTTGCCAACGCACTGGATATTGAATCTGTCGCTATCGTCGAAAAAGATTA
TTTTGTGGTTAATCTTTTAAAGTTACTAAAAGAAATAAAACCAGAAACACATACTCTCGTGTTTGCAGGAGGTACCGCAT
TGTCAAAAGCAGGTATCTCATTGAACAGAATGTCAGAAGATATTGATATAAAGCTCGTGCCAACAGAGAACTTTATGCAA
AATGGCAGAGACAAGAGAAGAAAAATTCGCAAGGAAATCGTGCAAATAATCACGGATGTTCTTCATAATTCTGACATTTT
CAGCCTGGATAATGAAAACGCCCGTATAACACGTGATGAGTATCGTTATAACGAGATCCCCGTACGTTATCCCCAGGCAT
TTGCCCAGGCCCCCTGTCTTCGTCCATTTATTAAGCTGGAGTTGATGGAAACCACTCTGCTGGAACATCCGGAAAGCAGA
GATATTTACTCACTTGTCACGGAGGTAACGGGTAATGGCACGCCTGTAACAGCATTCCCCTGTGCCACCATTTTATCCAC
TCAGGCTGAAAAGCTCATATCCATGATGCGAAGAACAGCCATACTTCTTCGCAATCCCGAACAACAGGATGATGAGTCCC
TGGTACGCCACATTTACGACAATTATTGCATTGTCAGGGAAAAAGGTGTGAATGTTCCAGTACTGAAAAATTTTGTTCAG
GTATGCATTCAACAGGATATTGAGCGCTATGGTAACCAGCACCCACAATTTTGTAACTCACCTGTTGATGAACTTAAAAA
AGGGCTGGATGCACTCCGGGATGATCCTGTACACAAATTGCGTTTTCAACGATTTGTTAAACCGATGGTATTTGGTAATA
CACAGATTGACTGGGAAGAAGCCTACTCCTGTTTCAGACAAACAGCGTTGAGTGTTCTGACCAGCTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14595.97 Da        Isoelectric Point: 10.9440

>AT50507 WP_000208385.1 NZ_CP010122:c5195288-5194893 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNVITGKIMPAAPGGSAAVITE
ALDLLNIRYSLIGATECYNKGQSTQIPVSPEFKTPPRFKRVLVVGKSKINA

Download         Length: 396 bp

>AT50507 NZ_CP010122:c5195288-5194893 [Escherichia coli]
ATGACTACAAAAGACCGTATTCAGTCCCGACTGAACCGTTCAAAGCGTTATGTGTTCACCCGGGATGACTTCAGGGATAT
CGCTGGCTATGATCAGGTTGGCAGAGCTCTTCGTACACTGGTAAACGAAGGTAAGTTGATGAAGGTGGGCTATGGTGTTT
ACACCAAAGCCCGTCGCAACGTTATTACAGGAAAAATAATGCCTGCAGCACCTGGTGGCTCTGCTGCTGTAATCACCGAA
GCCCTGGATCTTTTGAATATCAGATACAGCTTGATCGGCGCAACAGAATGCTACAATAAAGGTCAGTCCACACAGATTCC
GGTGTCTCCGGAGTTCAAAACACCTCCTCGCTTTAAAAGAGTGTTAGTTGTAGGGAAAAGTAAAATCAATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7ZRI5

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q1C5A3

References