Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 3845046..3845881 | Replicon | chromosome |
Accession | NZ_CP010122 | ||
Organism | Escherichia coli strain C5 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | A0A1L4J186 |
Locus tag | RG28_RS20500 | Protein ID | WP_000854742.1 |
Coordinates | 3845504..3845881 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | A0A1L4J164 |
Locus tag | RG28_RS20495 | Protein ID | WP_001406130.1 |
Coordinates | 3845046..3845414 (+) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
RG28_RS20470 | 3842707..3843525 | + | 819 | WP_001234392.1 | DUF945 domain-containing protein | - |
RG28_RS20475 | 3843617..3844102 | + | 486 | WP_000213706.1 | antirestriction protein | - |
RG28_RS20480 | 3844117..3844593 | + | 477 | WP_021566731.1 | RadC family protein | - |
RG28_RS20485 | 3844662..3844883 | + | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
RG28_RS20495 | 3845046..3845414 | + | 369 | WP_001406130.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
RG28_RS20500 | 3845504..3845881 | + | 378 | WP_000854742.1 | TA system toxin CbtA family protein | Toxin |
RG28_RS20505 | 3845878..3846366 | + | 489 | WP_000777551.1 | hypothetical protein | - |
RG28_RS20510 | 3846378..3846575 | + | 198 | WP_000839267.1 | DUF957 domain-containing protein | - |
RG28_RS31420 | 3847771..3848280 | + | 510 | WP_187655784.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | - | gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC | 3788869..3893303 | 104434 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14236.28 Da Isoelectric Point: 8.2976
>T50501 WP_000854742.1 NZ_CP010122:3845504-3845881 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SVCTHSQLINSIDILRARRATGLMTRSNYRMVNDITRGKHSEAKR
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SVCTHSQLINSIDILRARRATGLMTRSNYRMVNDITRGKHSEAKR
Download Length: 378 bp
>T50501 NZ_CP010122:3845504-3845881 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACACCATTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGTCTGTACCCACTCTCAGTTAATAAACAGCATCGATATTCTACGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCACCCGGGGTAAACATTCGGAGGCGAAACGATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACACCATTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGTCTGTACCCACTCTCAGTTAATAAACAGCATCGATATTCTACGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCACCCGGGGTAAACATTCGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13717.53 Da Isoelectric Point: 7.0269
>AT50501 WP_001406130.1 NZ_CP010122:3845046-3845414 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTSETKK
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTSETKK
Download Length: 369 bp
>AT50501 NZ_CP010122:3845046-3845414 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCAGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA
GTGTCAGACAAACTCTCCGGGATAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCAGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1L4J186 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1L4J164 |