Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 5325703..5326229 | Replicon | chromosome |
| Accession | NZ_CP010119 | ||
| Organism | Escherichia coli strain C3 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | RG26_RS28700 | Protein ID | WP_000323025.1 |
| Coordinates | 5325703..5325990 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | RG26_RS28705 | Protein ID | WP_000534858.1 |
| Coordinates | 5325990..5326229 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RG26_RS28660 | 5320738..5320953 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| RG26_RS31060 | 5321173..5321343 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| RG26_RS28665 | 5321707..5321922 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| RG26_RS28670 | 5322222..5322434 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| RG26_RS30655 | 5322489..5322578 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| RG26_RS28675 | 5322846..5323598 | - | 753 | WP_001047135.1 | antitermination protein | - |
| RG26_RS28680 | 5323612..5324661 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| RG26_RS28685 | 5324663..5324941 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| RG26_RS28690 | 5325008..5325259 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| RG26_RS28695 | 5325476..5325631 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| RG26_RS28700 | 5325703..5325990 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| RG26_RS28705 | 5325990..5326229 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| RG26_RS28710 | 5326254..5326559 | + | 306 | WP_071527819.1 | hypothetical protein | - |
| RG26_RS28720 | 5326762..5327094 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| RG26_RS28725 | 5327531..5328871 | - | 1341 | WP_000589015.1 | ISNCY family transposase | - |
| RG26_RS28730 | 5328905..5329324 | - | 420 | WP_001151196.1 | DUF977 family protein | - |
| RG26_RS28735 | 5329365..5330330 | - | 966 | WP_000054504.1 | hypothetical protein | - |
| RG26_RS28740 | 5330311..5330832 | - | 522 | WP_000705349.1 | hypothetical protein | - |
| RG26_RS28745 | 5330816..5331043 | - | 228 | WP_000476993.1 | transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 5283142..5348509 | 65367 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T50441 WP_000323025.1 NZ_CP010119:c5325990-5325703 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T50441 NZ_CP010119:c5325990-5325703 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT50441 WP_000534858.1 NZ_CP010119:c5326229-5325990 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT50441 NZ_CP010119:c5326229-5325990 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|