Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | paaR-paaA-parE/- |
Location | 4770042..4770523 | Replicon | chromosome |
Accession | NZ_CP010119 | ||
Organism | Escherichia coli strain C3 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | A0A0D7YS45 |
Locus tag | RG26_RS25570 | Protein ID | WP_014966210.1 |
Coordinates | 4770042..4770332 (-) | Length | 97 a.a. |
Antitoxin (Protein)
Gene name | paaA | Uniprot ID | A0A0D7Y007 |
Locus tag | RG26_RS25575 | Protein ID | WP_000100896.1 |
Coordinates | 4770332..4770523 (-) | Length | 64 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
RG26_RS25530 | 4765399..4765668 | - | 270 | WP_000003742.1 | excisionase | - |
RG26_RS25535 | 4765730..4768201 | - | 2472 | WP_073519354.1 | exonuclease | - |
RG26_RS25540 | 4768294..4768485 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
RG26_RS25545 | 4768482..4768670 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
RG26_RS25550 | 4769071..4769235 | + | 165 | WP_001331716.1 | hypothetical protein | - |
RG26_RS25555 | 4769239..4769457 | - | 219 | WP_001171974.1 | hypothetical protein | - |
RG26_RS25565 | 4769617..4769772 | - | 156 | WP_000379575.1 | DUF1391 family protein | - |
RG26_RS25570 | 4770042..4770332 | - | 291 | WP_014966210.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
RG26_RS25575 | 4770332..4770523 | - | 192 | WP_000100896.1 | hypothetical protein | Antitoxin |
RG26_RS25580 | 4770541..4771041 | - | 501 | WP_000823909.1 | helix-turn-helix transcriptional regulator | - |
RG26_RS25585 | 4771149..4771424 | + | 276 | WP_001048458.1 | helix-turn-helix domain-containing protein | - |
RG26_RS25590 | 4771408..4771833 | + | 426 | WP_000693918.1 | Rha family transcriptional regulator | - |
RG26_RS30570 | 4771905..4772921 | + | 1017 | WP_001262344.1 | hypothetical protein | - |
RG26_RS30575 | 4772833..4773375 | + | 543 | WP_072130322.1 | replication protein | - |
RG26_RS25605 | 4773409..4774179 | + | 771 | WP_000450649.1 | DUF1627 domain-containing protein | - |
RG26_RS25610 | 4774195..4774617 | + | 423 | WP_001151239.1 | DUF977 family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | espW / espM2 | 4757143..4818532 | 61389 | |
- | flank | IS/Tn | - | - | 4774696..4775676 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11176.05 Da Isoelectric Point: 9.9854
>T50433 WP_014966210.1 NZ_CP010119:c4770332-4770042 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKTC
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKTC
Download Length: 291 bp
>T50433 NZ_CP010119:c4770332-4770042 [Escherichia coli]
ATGCTGCCCATTTTATGGCTACCTTCTGCACGTGATGATTTACGTCAGATCGTAGCCTATATTGCTAAGGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTACTGAACACCCTTATCTGTACCCACCGAGCG
AAAGAGTTCCAAGTCTTCGTGAGATAGTGACTCATCCTAACTACATAATACTTTACCGAGTAACAGCATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGACAGTATCCAAACAAAACCTGTTAA
ATGCTGCCCATTTTATGGCTACCTTCTGCACGTGATGATTTACGTCAGATCGTAGCCTATATTGCTAAGGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTACTGAACACCCTTATCTGTACCCACCGAGCG
AAAGAGTTCCAAGTCTTCGTGAGATAGTGACTCATCCTAACTACATAATACTTTACCGAGTAACAGCATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGACAGTATCCAAACAAAACCTGTTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7033.83 Da Isoelectric Point: 4.0270
>AT50433 WP_000100896.1 NZ_CP010119:c4770523-4770332 [Escherichia coli]
MSTALSPIISEFETVEQENSYNEWLRTKVAASLSDPRPAIPHDEVMAEMENLIAQLAATNRSE
MSTALSPIISEFETVEQENSYNEWLRTKVAASLSDPRPAIPHDEVMAEMENLIAQLAATNRSE
Download Length: 192 bp
>AT50433 NZ_CP010119:c4770523-4770332 [Escherichia coli]
ATGAGTACAGCCCTTTCCCCGATAATTTCTGAATTTGAAACAGTCGAACAAGAAAACAGCTATAACGAATGGTTGCGAAC
CAAAGTGGCAGCAAGCCTCTCAGATCCCCGTCCTGCAATTCCACATGACGAAGTAATGGCTGAAATGGAAAACCTTATTG
CTCAATTAGCTGCAACGAACAGGAGTGAGTAA
ATGAGTACAGCCCTTTCCCCGATAATTTCTGAATTTGAAACAGTCGAACAAGAAAACAGCTATAACGAATGGTTGCGAAC
CAAAGTGGCAGCAAGCCTCTCAGATCCCCGTCCTGCAATTCCACATGACGAAGTAATGGCTGAAATGGAAAACCTTATTG
CTCAATTAGCTGCAACGAACAGGAGTGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0D7YS45 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0D7Y007 |