Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 3465938..3466464 | Replicon | chromosome |
| Accession | NZ_CP010119 | ||
| Organism | Escherichia coli strain C3 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | RG26_RS18480 | Protein ID | WP_000323025.1 |
| Coordinates | 3466177..3466464 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | RG26_RS18475 | Protein ID | WP_000534858.1 |
| Coordinates | 3465938..3466177 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RG26_RS18435 | 3461124..3461351 | + | 228 | WP_000476993.1 | transcriptional regulator | - |
| RG26_RS18440 | 3461335..3461856 | + | 522 | WP_000705349.1 | hypothetical protein | - |
| RG26_RS18445 | 3461837..3462802 | + | 966 | WP_000054504.1 | hypothetical protein | - |
| RG26_RS18450 | 3462843..3463262 | + | 420 | WP_001151196.1 | DUF977 family protein | - |
| RG26_RS18455 | 3463296..3464636 | + | 1341 | WP_000589015.1 | ISNCY family transposase | - |
| RG26_RS18460 | 3465073..3465405 | - | 333 | WP_001317460.1 | FlxA-like family protein | - |
| RG26_RS18470 | 3465608..3465913 | - | 306 | WP_071527819.1 | hypothetical protein | - |
| RG26_RS18475 | 3465938..3466177 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| RG26_RS18480 | 3466177..3466464 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| RG26_RS18485 | 3466536..3466691 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| RG26_RS18490 | 3466908..3467159 | + | 252 | WP_000980994.1 | hypothetical protein | - |
| RG26_RS18495 | 3467226..3467504 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| RG26_RS18500 | 3467506..3468555 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| RG26_RS18505 | 3468569..3469321 | + | 753 | WP_001047135.1 | antitermination protein | - |
| RG26_RS30405 | 3469589..3469678 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| RG26_RS18510 | 3469733..3469945 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| RG26_RS18515 | 3470245..3470460 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| RG26_RS31000 | 3470824..3470994 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| RG26_RS18520 | 3471214..3471429 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3452371..3502505 | 50134 | |
| - | inside | Prophage | - | - | 3419987..3502505 | 82518 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T50430 WP_000323025.1 NZ_CP010119:3466177-3466464 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T50430 NZ_CP010119:3466177-3466464 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT50430 WP_000534858.1 NZ_CP010119:3465938-3466177 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT50430 NZ_CP010119:3465938-3466177 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|