Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2378812..2379644 Replicon chromosome
Accession NZ_CP010119
Organism Escherichia coli strain C3

Toxin (Protein)


Gene name yeeV Uniprot ID F4TJC5
Locus tag RG26_RS12365 Protein ID WP_001094452.1
Coordinates 2379270..2379644 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4TJC4
Locus tag RG26_RS12360 Protein ID WP_001285579.1
Coordinates 2378812..2379180 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG26_RS12340 2376562..2377379 + 818 Protein_2193 DUF945 domain-containing protein -
RG26_RS12345 2377471..2377956 + 486 WP_000206663.1 antirestriction protein -
RG26_RS12350 2377972..2378448 + 477 WP_001186706.1 RadC family protein -
RG26_RS12355 2378511..2378732 + 222 WP_000692345.1 DUF987 domain-containing protein -
RG26_RS12360 2378812..2379180 + 369 WP_001285579.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
RG26_RS12365 2379270..2379644 + 375 WP_001094452.1 TA system toxin CbtA family protein Toxin
RG26_RS12370 2379641..2380132 + 492 WP_000976868.1 hypothetical protein -
RG26_RS12375 2380144..2380341 + 198 WP_000772035.1 DUF957 domain-containing protein -
RG26_RS12380 2380438..2381280 + 843 WP_001290259.1 DUF4942 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14014.86 Da        Isoelectric Point: 7.2920

>T50418 WP_001094452.1 NZ_CP010119:2379270-2379644 [Escherichia coli]
MNTLPDTHVREASRCSSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSTDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T50418 NZ_CP010119:2379270-2379644 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCTCATCTCCCGTAACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTAAATGACACACCGTTCTCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCACCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13580.39 Da        Isoelectric Point: 7.3223

>AT50418 WP_001285579.1 NZ_CP010119:2378812-2379180 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSCGYVYLAVYPTSETKK

Download         Length: 369 bp

>AT50418 NZ_CP010119:2378812-2379180 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAAAGGGCTGACCTGCAAAGCCGACACCCTCGGTAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7YIM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8DWX2

References