Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3388542..3389374 Replicon chromosome
Accession NZ_CP010116
Organism Escherichia coli strain C1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1L4HFA4
Locus tag RC72_RS17445 Protein ID WP_032163901.1
Coordinates 3389000..3389374 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag RC72_RS17440 Protein ID WP_001295723.1
Coordinates 3388542..3388910 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RC72_RS17400 3383658..3384476 + 819 WP_040061766.1 DUF945 domain-containing protein -
RC72_RS17405 3384531..3384923 + 393 Protein_3123 antirestriction protein -
RC72_RS17410 3385008..3385754 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
RC72_RS17415 3385769..3387310 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
RC72_RS17420 3387478..3387603 + 126 WP_115209348.1 antirestriction protein -
RC72_RS17425 3387619..3388095 + 477 WP_001186726.1 RadC family protein -
RC72_RS17430 3388158..3388379 + 222 WP_000692345.1 DUF987 domain-containing protein -
RC72_RS17440 3388542..3388910 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
RC72_RS17445 3389000..3389374 + 375 WP_032163901.1 TA system toxin CbtA family protein Toxin
RC72_RS17450 3389371..3389565 + 195 WP_000988600.1 hypothetical protein -
RC72_RS25775 3389578..3389691 + 114 WP_001161660.1 DUF957 domain-containing protein -
RC72_RS25320 3389980..3390108 - 129 Protein_3133 transposase domain-containing protein -
RC72_RS17460 3390180..3390362 + 183 WP_001016348.1 hypothetical protein -
RC72_RS17465 3390463..3390792 - 330 WP_000450409.1 DUF496 family protein -
RC72_RS17470 3390964..3392022 - 1059 WP_001200891.1 FUSC family protein -
RC72_RS17475 3392220..3392693 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
RC72_RS17480 3392812..3393978 - 1167 WP_042031746.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13919.89 Da        Isoelectric Point: 7.7760

>T50383 WP_032163901.1 NZ_CP010116:3389000-3389374 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T50383 NZ_CP010116:3389000-3389374 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT50383 WP_001295723.1 NZ_CP010116:3388542-3388910 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT50383 NZ_CP010116:3388542-3388910 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L4HFA4

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References