Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 3311088..3311741 Replicon chromosome
Accession NZ_CP010114
Organism Mycobacterium avium subsp. paratuberculosis strain E93

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag RE97_RS15005 Protein ID WP_003872880.1
Coordinates 3311088..3311549 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID Q742J1
Locus tag RE97_RS15010 Protein ID WP_003872881.1
Coordinates 3311553..3311741 (-) Length 63 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RE97_RS14990 3307580..3307966 - 387 WP_003872877.1 hypothetical protein -
RE97_RS14995 3308006..3309589 - 1584 WP_003872878.1 DUF4185 domain-containing protein -
RE97_RS15000 3310585..3311019 - 435 WP_003877359.1 hypothetical protein -
RE97_RS15005 3311088..3311549 - 462 WP_003872880.1 SRPBCC family protein Toxin
RE97_RS15010 3311553..3311741 - 189 WP_003872881.1 antitoxin Antitoxin
RE97_RS15015 3311804..3314176 - 2373 WP_003872882.1 HAD-IC family P-type ATPase -
RE97_RS15020 3314173..3315759 - 1587 WP_003872883.1 serine hydrolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-142)

Antitoxin

(4-51)


Sequences


Toxin        


Download         Length: 154 a.a.        Molecular weight: 16626.19 Da        Isoelectric Point: 9.5654

>T50357 WP_003872880.1 NZ_CP010114:c3311549-3311088 [Mycobacterium avium subsp. paratuberculosis]
VAKLSGSIDVPLPPEVAWQHASDLSRYKEWLTIHRVWRSTLPDQIDKGTVVESIVEVKGMLNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKVQPKADGSVVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFARSDPSTNGHR

Download         Length: 462 bp

>T50357 NZ_CP010114:c3311549-3311088 [Mycobacterium avium subsp. paratuberculosis]
GTGGCCAAGCTTTCCGGATCCATCGATGTTCCGCTGCCCCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGAGTGGCTGACCATTCACCGGGTGTGGCGCAGCACCTTGCCCGACCAGATCGACAAGGGCACCGTCGTCGAGTCGA
TCGTCGAGGTCAAAGGCATGCTCAACCGGATCAAATGGACGGTGGTGCGCTACAAGCCACCGGAGGGGATGACGCTCAAC
GGCGACGGCGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGGTGCAGCCCAAGGCGGACGGTTCCGTCGTCAGCTTCGA
CGTGCACCTCGGCGGTCCGGCGCTGTTCGGGCCCATCGGCATGATCGTCGCGGCCGCGCTGCGCGGCGACATCGACCAGT
CGCTGGAGAACTTCGTCACGGTGTTCGCCCGATCGGATCCGAGCACCAACGGTCATCGCTGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6745.42 Da        Isoelectric Point: 4.4865

>AT50357 WP_003872881.1 NZ_CP010114:c3311741-3311553 [Mycobacterium avium subsp. paratuberculosis]
MGFLDKAKDLLSQNADKVEMAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKATGATETGDQQG

Download         Length: 189 bp

>AT50357 NZ_CP010114:c3311741-3311553 [Mycobacterium avium subsp. paratuberculosis]
ATGGGATTCCTGGACAAGGCCAAGGACCTGTTGTCGCAGAACGCCGACAAGGTCGAGATGGCCATCGACAAGGCCGGCGA
GTTCGTCGACGAGAAGACCCAGGGCAAGTACTCCGACACCATCCACCAGGTGCAGGAGCAGGCCAAGAAGGCCACCGGCG
CCACCGAGACCGGCGACCAGCAGGGCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E2WC18

References