Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1187400..1187964 Replicon chromosome
Accession NZ_CP010114
Organism Mycobacterium avium subsp. paratuberculosis strain E93

Toxin (Protein)


Gene name vapC Uniprot ID X7VBD8
Locus tag RE97_RS05640 Protein ID WP_003875391.1
Coordinates 1187593..1187964 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7L5MGM2
Locus tag RE97_RS22630 Protein ID WP_003875390.1
Coordinates 1187400..1187606 (+) Length 69 a.a.

Genomic Context

RE97_RS05620RE97_RS05630RE97_RS05635RE97_RS22630RE97_RS05640RE97_RS05645RE97_RS05650RE97_RS05655RE97_RS22635RE97_RS05660RE97_RS05665RE97_RS05670RE97_RS05680RE97_RS05625RE97_RS05675
Location: 1182654..1183652 (999 bp)
Type: Others
Protein ID: WP_003875386.1
Location: 1185014..1186087 (1074 bp)
Type: Others
Protein ID: WP_010949695.1
Location: 1186287..1187231 (945 bp)
Type: Others
Protein ID: WP_003875389.1
Location: 1187400..1187606 (207 bp)
Type: Antitoxin
Protein ID: WP_003875390.1
Location: 1187593..1187964 (372 bp)
Type: Toxin
Protein ID: WP_003875391.1
Location: 1188064..1188504 (441 bp)
Type: Others
Protein ID: WP_010949694.1
Location: 1188560..1188835 (276 bp)
Type: Others
Protein ID: WP_003878531.1
Location: 1188937..1189335 (399 bp)
Type: Others
Protein ID: WP_003875394.1
Location: 1189402..1189785 (384 bp)
Type: Others
Protein ID: WP_003875395.1
Location: 1189855..1190208 (354 bp)
Type: Others
Protein ID: WP_003875396.1
Location: 1190365..1190889 (525 bp)
Type: Others
Protein ID: WP_033713819.1
Location: 1191300..1191624 (325 bp)
Type: Others
Protein ID: Protein_1145
Location: 1192430..1192627 (198 bp)
Type: Others
Protein ID: WP_016706054.1
Location: 1183676..1184883 (1208 bp)
Type: Others
Protein ID: Protein_1134
Location: 1191629..1192312 (684 bp)
Type: Others
Protein ID: WP_003875399.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
RE97_RS056201182654..1183652+999WP_003875386.14-hydroxy-3-methylbut-2-enyl diphosphate reductase-
RE97_RS056251183676..1184883-1208Protein_1134hypothetical protein-
RE97_RS056301185014..1186087+1074WP_010949695.1redox-regulated ATPase YchF-
RE97_RS056351186287..1187231+945WP_003875389.1HNH endonuclease-
RE97_RS226301187400..1187606+207WP_003875390.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
RE97_RS056401187593..1187964+372WP_003875391.1type II toxin-antitoxin system VapC family toxinToxin
RE97_RS056451188064..1188504+441WP_010949694.1nitroreductase family deazaflavin-dependent oxidoreductase-
RE97_RS056501188560..1188835+276WP_003878531.1hypothetical protein-
RE97_RS056551188937..1189335+399WP_003875394.1VOC family protein-
RE97_RS226351189402..1189785+384WP_003875395.1hypothetical protein-
RE97_RS056601189855..1190208+354WP_003875396.1hypothetical protein-
RE97_RS056651190365..1190889+525WP_033713819.1glycoside hydrolase-
RE97_RS056701191300..1191624+325Protein_1145antibiotic biosynthesis monooxygenase-
RE97_RS056751191629..1192312-684WP_003875399.1hypothetical protein-
RE97_RS056801192430..1192627+198WP_016706054.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13770.14 Da        Isoelectric Point: 6.6003

>T50354 WP_003875391.1 NZ_CP010114:1187593-1187964 [Mycobacterium avium subsp. paratuberculosis]
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVECHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL

Download         Length: 372 bp

>T50354 NZ_CP010114:1187593-1187964 [Mycobacterium avium subsp. paratuberculosis]
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGTTGACGCATGCGGAGGTCCTTCATCTCGTCGAATGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTCGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7231.22 Da        Isoelectric Point: 11.0634

>AT50354 WP_003875390.1 NZ_CP010114:1187400-1187606 [Mycobacterium avium subsp. paratuberculosis]
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRAPADDSR

Download         Length: 207 bp

>AT50354 NZ_CP010114:1187400-1187606 [Mycobacterium avium subsp. paratuberculosis]
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGGCACCCGCCGATGATTCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E2WB37

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7L5MGM2

References