Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2382996..2383974 | Replicon | chromosome |
| Accession | NZ_CP010106 | ||
| Organism | Bacillus thuringiensis serovar indiana strain HD521 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | NF53_RS12440 | Protein ID | WP_000624979.1 |
| Coordinates | 2382996..2383733 (+) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | W8YZL5 |
| Locus tag | NF53_RS12445 | Protein ID | WP_000237818.1 |
| Coordinates | 2383846..2383974 (+) | Length | 43 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NF53_RS12415 | 2378612..2379019 | + | 408 | WP_000072493.1 | VOC family protein | - |
| NF53_RS12420 | 2379041..2379421 | + | 381 | WP_000497672.1 | hypothetical protein | - |
| NF53_RS12425 | 2379579..2381264 | - | 1686 | WP_033689678.1 | alpha-keto acid decarboxylase family protein | - |
| NF53_RS12430 | 2381372..2381854 | + | 483 | WP_000191888.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| NF53_RS12435 | 2382021..2382758 | + | 738 | WP_000594151.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| NF53_RS12440 | 2382996..2383733 | + | 738 | WP_000624979.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| NF53_RS12445 | 2383846..2383974 | + | 129 | WP_000237818.1 | hypothetical protein | Antitoxin |
| NF53_RS12450 | 2384047..2384223 | + | 177 | WP_000852627.1 | stage II sporulation protein SB | - |
| NF53_RS12455 | 2384243..2384632 | - | 390 | WP_000713864.1 | YxeA family protein | - |
| NF53_RS12460 | 2384844..2386313 | + | 1470 | WP_000287533.1 | beta-Ala-His dipeptidase | - |
| NF53_RS12465 | 2386558..2387367 | + | 810 | WP_000664542.1 | C39 family peptidase | - |
| NF53_RS12470 | 2387393..2387995 | + | 603 | WP_000517260.1 | hypothetical protein | - |
| NF53_RS12475 | 2388236..2388487 | - | 252 | WP_000827561.1 | response regulator transcription factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28311.04 Da Isoelectric Point: 8.2998
>T50353 WP_000624979.1 NZ_CP010106:2382996-2383733 [Bacillus thuringiensis serovar indiana]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHMEQLNEQKAVQVENVGVIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHMEQLNEQKAVQVENVGVIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T50353 NZ_CP010106:2382996-2383733 [Bacillus thuringiensis serovar indiana]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
AGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTAGATATTGCATTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCCATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACGACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATACGGGGAAAAGATTGGCGCGAAAATT
GTTGTTTTTGAAGCCGCGAAAGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATGGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGGGTTATACCAGCAAAAATAGTAAGTGACG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
AGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTAGATATTGCATTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCCATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACGACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATACGGGGAAAAGATTGGCGCGAAAATT
GTTGTTTTTGAAGCCGCGAAAGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATGGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGGGTTATACCAGCAAAAATAGTAAGTGACG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
Antitoxin
Download Length: 43 a.a. Molecular weight: 5011.40 Da Isoelectric Point: 3.9150
>AT50353 WP_000237818.1 NZ_CP010106:2383846-2383974 [Bacillus thuringiensis serovar indiana]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS
Download Length: 129 bp
>AT50353 NZ_CP010106:2383846-2383974 [Bacillus thuringiensis serovar indiana]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|