Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 554348..554984 Replicon chromosome
Accession NZ_CP010075
Organism Bacillus sp. WP8

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag QR42_RS02615 Protein ID WP_024425388.1
Coordinates 554634..554984 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag QR42_RS02610 Protein ID WP_003214273.1
Coordinates 554348..554629 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QR42_RS02590 550487..551092 - 606 WP_039176707.1 rhomboid family intramembrane serine protease -
QR42_RS02595 551188..551553 + 366 WP_039176708.1 holo-ACP synthase -
QR42_RS02600 551714..552730 + 1017 WP_087975235.1 outer membrane lipoprotein carrier protein LolA -
QR42_RS02605 552872..554053 + 1182 WP_039176711.1 alanine racemase -
QR42_RS02610 554348..554629 + 282 WP_003214273.1 hypothetical protein Antitoxin
QR42_RS02615 554634..554984 + 351 WP_024425388.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QR42_RS02620 555101..555931 + 831 WP_039176712.1 RsbT co-antagonist protein RsbRA -
QR42_RS02625 555936..556304 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
QR42_RS02630 556307..556708 + 402 WP_024425390.1 anti-sigma regulatory factor -
QR42_RS02635 556719..557726 + 1008 WP_039176714.1 PP2C family protein-serine/threonine phosphatase -
QR42_RS02640 557786..558115 + 330 WP_017358393.1 anti-sigma factor antagonist -
QR42_RS02645 558112..558600 + 489 WP_039176716.1 anti-sigma B factor RsbW -
QR42_RS02650 558566..559354 + 789 WP_024427378.1 RNA polymerase sigma factor SigB -
QR42_RS02655 559354..559953 + 600 WP_039176718.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T50347 WP_024425388.1 NZ_CP010075:554634-554984 [Bacillus sp. WP8]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T50347 NZ_CP010075:554634-554984 [Bacillus sp. WP8]
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCAGT
ATTGGTGATTCAAAATGACATTGGAAATCGCTTCAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTGATGCAAAGCGCTACGGCTTTGAACGAGATTCTGTCATTCTCTTGGAGCAGATT
CGTACAATCGATAAACAAAGATTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT50347 WP_003214273.1 NZ_CP010075:554348-554629 [Bacillus sp. WP8]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT50347 NZ_CP010075:554348-554629 [Bacillus sp. WP8]
TTGTCTGAATCCAGCGCAACAAACGAAATGAAGATTCGACTACCGGAGGCTTTGATGTCTGAAATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGTAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAGGCACAATACGCAGAATTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7G713

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References