Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 40335..40869 Replicon plasmid unnamed1
Accession NZ_CP010069
Organism Yersinia pseudotuberculosis str. PA3606

Toxin (Protein)


Gene name parE Uniprot ID Q663N8
Locus tag BZ19_RS21520 Protein ID WP_002213360.1
Coordinates 40570..40869 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9ZGW3
Locus tag BZ19_RS21515 Protein ID WP_002224342.1
Coordinates 40335..40577 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZ19_RS21500 36855..38021 + 1167 WP_002220902.1 plasmid-partitioning protein SopA -
BZ19_RS21505 38018..38983 + 966 WP_042659889.1 ParB/RepB/Spo0J family plasmid partition protein -
BZ19_RS24210 39143..39469 + 327 WP_158499626.1 hypothetical protein -
BZ19_RS24460 39619..39792 - 174 WP_165285961.1 hypothetical protein -
BZ19_RS23625 39877..40169 + 293 Protein_54 IS6 family transposase -
BZ19_RS21515 40335..40577 + 243 WP_002224342.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BZ19_RS21520 40570..40869 + 300 WP_002213360.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BZ19_RS21525 41009..41668 - 660 WP_072080538.1 type III secretion system effector GTPase activator YopE -
BZ19_RS21530 41862..42254 + 393 WP_002213403.1 type III secretion system chaperone SycE/YerA -
BZ19_RS21535 42317..42961 - 645 Protein_59 IS3 family transposase -
BZ19_RS21545 43064..44236 + 1173 WP_042659891.1 IS21 family transposase -
BZ19_RS21550 44236..44634 + 399 Protein_61 ATP-binding protein -
BZ19_RS21555 45012..45437 + 426 WP_002213267.1 type III secretion system chaperone SycH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - lcrQ/yscM / yscL / yscK / ylpB/yscJ / lcrO/yscI / yopR/yscH/lcrP / yscG / yscF / yscE / yscD / yscC / yscB / virG/yscW / yscU / yscT / yscS / yscR / yscQ / yscP / yscO / yscN / lcrE/yopN / tyeA / sycN / yscX / yscY / yscV/lcrD / lcrR / lcrG / lcrV / sycD/lcrH / yopB / yopD / yopM / sycT / yopT / yopK/yopQ / yopE / sycE/yerA / sycH / yadA / yopO/ypkA / yopJ/yopP / yopH 1..74956 74956


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

Antitoxin ParD

(5-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11632.19 Da        Isoelectric Point: 5.5114

>T50342 WP_002213360.1 NZ_CP010069:40570-40869 [Yersinia pseudotuberculosis str. PA3606]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE

Download         Length: 300 bp

>T50342 NZ_CP010069:40570-40869 [Yersinia pseudotuberculosis str. PA3606]
GTGTATAAACTGTCTGAACTAGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCCAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGATATTCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGTTCAGGATTTTCCAGAGCATGAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8865.15 Da        Isoelectric Point: 6.4781

>AT50342 WP_002224342.1 NZ_CP010069:40335-40577 [Yersinia pseudotuberculosis str. PA3606]
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKDTSV

Download         Length: 243 bp

>AT50342 NZ_CP010069:40335-40577 [Yersinia pseudotuberculosis str. PA3606]
ATGGCTCACGTAACCAGCGTAACACTTGGAGAGCATTTAACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAATGTACCTGTGAGCCATCGTTTAATGGATGAGATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q663N8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1NQY6

References