Detailed information of TA system TA050341

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 4606227..4606927
• Replicon: chromosome
• Accession: NZ_CP010067
• Organism: Yersinia pseudotuberculosis str. PA3606

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: BZ19_RS20600
• Protein ID: WP_042659805.1
• Coordinates: 4606227..4606598 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: BZ19_RS20605
• Protein ID: WP_042659806.1
• Coordinates: 4606595..4606927 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZ19_RS20570	4602475..4602912	+	438	WP_042659800.1	hypothetical protein	-
BZ19_RS20575	4602932..4603735	+	804	WP_042659801.1	hypothetical protein	-
BZ19_RS20580	4603788..4603967	+	180	WP_042659802.1	hypothetical protein	-
BZ19_RS20585	4604003..4604449	+	447	WP_042659803.1	hypothetical protein	-
BZ19_RS20590	4604523..4605344	+	822	WP_004389304.1	DUF945 domain-containing protein	-
BZ19_RS20595	4605704..4606135	+	432	WP_042659804.1	antirestriction protein	-
BZ19_RS20600	4606227..4606598	+	372	WP_042659805.1	TA system toxin CbtA family protein	Toxin
BZ19_RS20605	4606595..4606927	+	333	WP_042659806.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
BZ19_RS20610	4607012..4607869	+	858	WP_042659807.1	DUF4942 domain-containing protein	-
BZ19_RS24450	4608258..4608737	+	480	WP_181812828.1	integrase arm-type DNA-binding domain-containing protein	-
BZ19_RS24455	4608774..4609524	+	751	Protein_3935	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (12-101)

Antitoxin

• Antitoxin CbeA (9-108)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13671.79 Da
• Isoelectric Point: 7.3553

>T50341 WP_042659805.1 NZ_CP010067:4606227-4606598 [Yersinia pseudotuberculosis str. PA3606]
MKPCPITSGALPVPVIYQRLLTFLLEHHYGLSLNDTPYHDEQAIAQQIEQGISVGDTINTLVEKYALVRIGRNGFSVLAQ
DPMLSKGDIARARQAVGLWRAHFPPTLLYPTESLNPIPQRPLT

Nucleotide

• Length: 372 bp

>T50341 NZ_CP010067:4606227-4606598 [Yersinia pseudotuberculosis str. PA3606]
ATGAAACCATGTCCCATCACATCGGGCGCATTACCCGTGCCTGTTATTTATCAGCGACTGCTCACTTTCCTGCTGGAGCA
CCACTACGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGCGATTGCGCAGCAGATAGAACAAGGGATTTCAG
TCGGCGACACCATCAACACACTGGTTGAGAAATATGCATTAGTGCGAATTGGTCGTAACGGGTTCAGCGTACTGGCACAA
GACCCGATGCTGAGCAAGGGTGATATCGCCCGCGCACGACAGGCCGTAGGGCTGTGGCGAGCACATTTTCCGCCCACGTT
GCTGTACCCAACCGAGTCCCTCAATCCTATTCCACAGAGACCGTTAACATGA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12146.75 Da
• Isoelectric Point: 6.9764

>AT50341 WP_042659806.1 NZ_CP010067:4606595-4606927 [Yersinia pseudotuberculosis str. PA3606]
MNNHMTTSPTWGLKRDITPRLGARLVQEGTHLHFLSDRANIVGTFSPQAAQALDVAFPALITKLESQLLSGQLDPRRQQG
ITVRHGEFVCDADTLGSHGYVYIAVYQELS

Nucleotide

• Length: 333 bp

>AT50341 NZ_CP010067:4606595-4606927 [Yersinia pseudotuberculosis str. PA3606]
ATGAATAACCACATGACTACTTCCCCAACATGGGGCCTGAAACGTGATATTACGCCGCGGTTGGGGGCCCGACTGGTACA
GGAGGGAACACACCTGCACTTTCTGAGTGACAGAGCCAATATTGTCGGCACCTTTTCCCCTCAAGCCGCTCAGGCTCTTG
ATGTGGCATTCCCAGCGCTGATAACCAAACTGGAGTCGCAGCTGCTGTCCGGCCAGCTTGACCCTCGCCGTCAGCAAGGC
ATTACCGTTCGGCATGGAGAATTTGTCTGTGACGCCGATACGCTGGGCAGTCACGGTTATGTCTATATCGCGGTGTATCA
GGAACTGTCTTGA