Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeV-yfjZ/CbtA-CbeA |
| Location | 2970297..2970985 | Replicon | chromosome |
| Accession | NZ_CP010067 | ||
| Organism | Yersinia pseudotuberculosis str. PA3606 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0U1QY13 |
| Locus tag | BZ19_RS13445 | Protein ID | WP_012104596.1 |
| Coordinates | 2970297..2970653 (+) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A0U1QVL0 |
| Locus tag | BZ19_RS13450 | Protein ID | WP_012104595.1 |
| Coordinates | 2970665..2970985 (+) | Length | 107 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BZ19_RS13405 | 2965823..2966443 | + | 621 | WP_012104606.1 | hypothetical protein | - |
| BZ19_RS13410 | 2966566..2967102 | + | 537 | WP_012104605.1 | DUF4339 domain-containing protein | - |
| BZ19_RS13415 | 2967206..2967673 | + | 468 | WP_012104604.1 | hypothetical protein | - |
| BZ19_RS13420 | 2967770..2968591 | + | 822 | WP_012104602.1 | DUF945 domain-containing protein | - |
| BZ19_RS13425 | 2968591..2968851 | + | 261 | WP_012104601.1 | hypothetical protein | - |
| BZ19_RS13430 | 2968979..2969410 | + | 432 | WP_012104600.1 | antirestriction protein | - |
| BZ19_RS13435 | 2969442..2969915 | + | 474 | WP_041175841.1 | DNA repair protein RadC | - |
| BZ19_RS13440 | 2969909..2970241 | + | 333 | WP_012104597.1 | hypothetical protein | - |
| BZ19_RS13445 | 2970297..2970653 | + | 357 | WP_012104596.1 | TA system toxin CbtA family protein | Toxin |
| BZ19_RS13450 | 2970665..2970985 | + | 321 | WP_012104595.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| BZ19_RS13455 | 2971081..2971947 | + | 867 | WP_012104594.1 | DUF4942 domain-containing protein | - |
| BZ19_RS13460 | 2972147..2972470 | + | 324 | WP_012104593.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| BZ19_RS13465 | 2972457..2972744 | + | 288 | WP_012104592.1 | helix-turn-helix transcriptional regulator | - |
| BZ19_RS13470 | 2973203..2973511 | - | 309 | Protein_2581 | site-specific integrase | - |
| BZ19_RS13475 | 2973535..2974164 | - | 630 | WP_041175740.1 | DUF2345 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | clpV/tssH / clpV/tssH / hcp/tssD / vasE/tssK / vipB/tssC / vipA/tssB / clpV/tssH / hcp/tssD / vasE/tssK / vipB/tssC / vipA/tssB | 2930907..2997472 | 66565 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12999.94 Da Isoelectric Point: 6.8771
>T50340 WP_012104596.1 NZ_CP010067:2970297-2970653 [Yersinia pseudotuberculosis str. PA3606]
MKPRATAQGALPVPVIYQQLLAFLLEHHYGLSLNDTPYHDEQVIAQQIEQGISVGDTINALVDKYALVRIGRNGFSALVQ
DPMLSKGDIARARQAAGLWRAHFPPTLLYPTESLNPIP
MKPRATAQGALPVPVIYQQLLAFLLEHHYGLSLNDTPYHDEQVIAQQIEQGISVGDTINALVDKYALVRIGRNGFSALVQ
DPMLSKGDIARARQAAGLWRAHFPPTLLYPTESLNPIP
Download Length: 357 bp
>T50340 NZ_CP010067:2970297-2970653 [Yersinia pseudotuberculosis str. PA3606]
ATGAAACCACGCGCCACAGCGCAGGGTGCATTGCCCGTGCCTGTTATTTATCAGCAACTGCTCGCTTTTCTGCTGGAGCA
CCACTATGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGTGATTGCACAGCAGATAGAACAAGGGATTTCAG
TGGGCGATACCATTAATGCATTGGTTGATAAATATGCATTAGTGCGAATTGGTCGTAACGGGTTCAGCGCACTGGTACAA
GACCCGATGCTGAGTAAGGGTGATATCGCCCGTGCTCGCCAGGCCGCAGGTCTGTGGCGTGCGCATTTTCCGCCAACGTT
GCTGTACCCAACCGAGTCCCTCAATCCTATTCCATAG
ATGAAACCACGCGCCACAGCGCAGGGTGCATTGCCCGTGCCTGTTATTTATCAGCAACTGCTCGCTTTTCTGCTGGAGCA
CCACTATGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGTGATTGCACAGCAGATAGAACAAGGGATTTCAG
TGGGCGATACCATTAATGCATTGGTTGATAAATATGCATTAGTGCGAATTGGTCGTAACGGGTTCAGCGCACTGGTACAA
GACCCGATGCTGAGTAAGGGTGATATCGCCCGTGCTCGCCAGGCCGCAGGTCTGTGGCGTGCGCATTTTCCGCCAACGTT
GCTGTACCCAACCGAGTCCCTCAATCCTATTCCATAG
Antitoxin
Download Length: 107 a.a. Molecular weight: 11579.17 Da Isoelectric Point: 7.4210
>AT50340 WP_012104595.1 NZ_CP010067:2970665-2970985 [Yersinia pseudotuberculosis str. PA3606]
MDNHMTTSPTWGLKRDITPRLGARLVQEGTHLHFLSDRANIVGTFSPQAAQALDVAFPALITKLESQMLSGALDPRRQQG
ITVRHGGFVCDADTLGSHGYVYIAVY
MDNHMTTSPTWGLKRDITPRLGARLVQEGTHLHFLSDRANIVGTFSPQAAQALDVAFPALITKLESQMLSGALDPRRQQG
ITVRHGGFVCDADTLGSHGYVYIAVY
Download Length: 321 bp
>AT50340 NZ_CP010067:2970665-2970985 [Yersinia pseudotuberculosis str. PA3606]
ATGGATAACCACATGACTACTTCCCCAACATGGGGCCTGAAACGTGATATTACGCCACGTTTGGGAGCCAGACTGGTGCA
GGAAGGAACACACCTGCACTTTCTGAGTGACAGAGCCAATATTGTCGGCACCTTTTCCCCTCAAGCCGCTCAGGCTCTTG
ATGTGGCATTCCCAGCGCTGATAACCAAACTGGAGTCGCAGATGCTGTCCGGGGCGCTGGATCCACGCCGTCAGCAAGGC
ATTACGGTTCGGCACGGGGGATTTGTCTGTGACGCCGATACGCTGGGCAGTCACGGTTATGTCTACATCGCGGTGTATTA
G
ATGGATAACCACATGACTACTTCCCCAACATGGGGCCTGAAACGTGATATTACGCCACGTTTGGGAGCCAGACTGGTGCA
GGAAGGAACACACCTGCACTTTCTGAGTGACAGAGCCAATATTGTCGGCACCTTTTCCCCTCAAGCCGCTCAGGCTCTTG
ATGTGGCATTCCCAGCGCTGATAACCAAACTGGAGTCGCAGATGCTGTCCGGGGCGCTGGATCCACGCCGTCAGCAAGGC
ATTACGGTTCGGCACGGGGGATTTGTCTGTGACGCCGATACGCTGGGCAGTCACGGTTATGTCTACATCGCGGTGTATTA
G
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U1QY13 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U1QVL0 |