Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2825781..2826453 Replicon chromosome
Accession NZ_CP010067
Organism Yersinia pseudotuberculosis str. PA3606

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag BZ19_RS12865 Protein ID WP_002215144.1
Coordinates 2825781..2826206 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag BZ19_RS12870 Protein ID WP_002209939.1
Coordinates 2826187..2826453 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZ19_RS12845 2821480..2821998 + 519 WP_011192956.1 flavodoxin FldB -
BZ19_RS12850 2822083..2823540 - 1458 WP_012303664.1 cell envelope integrity protein CreD -
BZ19_RS12855 2823625..2825058 - 1434 WP_042659630.1 two-component system sensor histidine kinase CreC -
BZ19_RS12860 2825083..2825781 - 699 WP_002209937.1 two-component system response regulator CreB -
BZ19_RS12865 2825781..2826206 - 426 WP_002215144.1 protein YgfX Toxin
BZ19_RS12870 2826187..2826453 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
BZ19_RS12875 2826770..2827762 + 993 WP_011192958.1 tRNA-modifying protein YgfZ -
BZ19_RS12880 2827835..2828332 - 498 WP_002209941.1 DUF2165 family protein -
BZ19_RS12885 2828641..2829342 - 702 WP_002209942.1 hemolysin III family protein -
BZ19_RS12890 2829544..2830647 - 1104 WP_012104675.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T50339 WP_002215144.1 NZ_CP010067:c2826206-2825781 [Yersinia pseudotuberculosis str. PA3606]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T50339 NZ_CP010067:c2826206-2825781 [Yersinia pseudotuberculosis str. PA3606]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT50339 WP_002209939.1 NZ_CP010067:c2826453-2826187 [Yersinia pseudotuberculosis str. PA3606]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT50339 NZ_CP010067:c2826453-2826187 [Yersinia pseudotuberculosis str. PA3606]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTTAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References