Detailed information of TA system TA050336

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1340089..1340602
• Replicon: chromosome
• Accession: NZ_CP010067
• Organism: Yersinia pseudotuberculosis str. PA3606

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A209AEM7
• Locus tag: BZ19_RS06150
• Protein ID: WP_012105238.1
• Coordinates: 1340089..1340373 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A386HFF3
• Locus tag: BZ19_RS06155
• Protein ID: WP_012105237.1
• Coordinates: 1340363..1340602 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZ19_RS06105	1335451..1335666	+	216	WP_041175774.1	peptidoglycan-binding protein LysM	-
BZ19_RS06110	1335666..1335929	+	264	Protein_1151	lysozyme	-
BZ19_RS06115	1336228..1336497	+	270	WP_041175773.1	hypothetical protein	-
BZ19_RS06120	1336714..1336950	-	237	WP_041175868.1	hypothetical protein	-
BZ19_RS06125	1336998..1337198	-	201	WP_197276493.1	DUF2158 domain-containing protein	-
BZ19_RS06130	1337675..1338184	+	510	WP_012105242.1	ParB/Srx family N-terminal domain-containing protein	-
BZ19_RS06135	1338196..1338795	+	600	WP_197276492.1	protein Mom	-
BZ19_RS06140	1338798..1339058	+	261	WP_012105240.1	hypothetical protein	-
BZ19_RS06145	1339062..1340078	+	1017	WP_012105239.1	terminase small subunit	-
BZ19_RS06150	1340089..1340373	-	285	WP_012105238.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BZ19_RS06155	1340363..1340602	-	240	WP_012105237.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BZ19_RS06160	1340729..1342372	+	1644	WP_012105236.1	phage terminase large subunit	-
BZ19_RS06165	1342375..1343760	+	1386	WP_012105235.1	DUF1073 domain-containing protein	-
BZ19_RS06170	1343819..1344568	+	750	WP_041175772.1	phage head morphogenesis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fliR / fliQ / fliP / fliN / fliM / fliL / fliJ / fliI / fliH / fliG / fliF / fliE / fliT / fliS / fliD / fliA / fliZ	1273445..1386599	113154

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-76)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11186.99 Da
• Isoelectric Point: 10.3007

>T50336 WP_012105238.1 NZ_CP010067:c1340373-1340089 [Yersinia pseudotuberculosis str. PA3606]
MTYNLDFDRRALKEWHKLGDTVRQQFKKKLLEVIKNPRVEANKLRDLPDCYKIKLRSAGYRLIYQVQDEKITVFVVAVGK
RDREEAYSEAGKRV

Nucleotide

• Length: 285 bp

>T50336 NZ_CP010067:c1340373-1340089 [Yersinia pseudotuberculosis str. PA3606]
ATGACTTATAATCTTGATTTTGATCGCCGGGCGCTGAAGGAATGGCATAAGCTCGGCGATACCGTACGTCAGCAATTTAA
GAAAAAGCTGCTCGAAGTGATTAAAAATCCACGCGTTGAAGCCAATAAACTGCGCGACTTGCCTGATTGCTACAAAATAA
AACTACGCAGCGCCGGATACCGCCTGATTTATCAGGTGCAAGACGAAAAAATCACGGTTTTTGTGGTTGCCGTGGGTAAA
CGGGATCGTGAAGAAGCCTACAGTGAAGCTGGCAAGCGCGTCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8836.12 Da
• Isoelectric Point: 4.5105

>AT50336 WP_012105237.1 NZ_CP010067:c1340602-1340363 [Yersinia pseudotuberculosis str. PA3606]
MGNINIRIDDDLKDRSYAVLEKLGVTPSDLLRQTLEYVAQSGKLPFKSVLLTDEDQALVAVVRERLANPQPVRVSLDDL

Nucleotide

• Length: 240 bp

>AT50336 NZ_CP010067:c1340602-1340363 [Yersinia pseudotuberculosis str. PA3606]
ATGGGTAATATTAATATTCGCATTGATGATGACTTAAAAGATCGTTCTTATGCGGTACTGGAAAAACTGGGCGTCACCCC
CTCTGATTTACTGCGCCAGACGCTGGAATATGTGGCACAAAGTGGCAAACTGCCCTTTAAATCCGTGTTGCTGACTGATG
AAGATCAAGCATTGGTCGCCGTAGTCAGAGAACGTTTAGCCAATCCACAACCGGTCAGGGTGTCACTGGATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A209AEM7