Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 404827..405447 Replicon chromosome
Accession NZ_CP010067
Organism Yersinia pseudotuberculosis str. PA3606

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag BZ19_RS01760 Protein ID WP_002208622.1
Coordinates 404827..405030 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0E8XFK3
Locus tag BZ19_RS01765 Protein ID WP_033847808.1
Coordinates 405079..405447 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BZ19_RS01740 400159..401448 + 1290 WP_002228344.1 ammonium transporter AmtB -
BZ19_RS01745 401709..402569 - 861 WP_012105571.1 acyl-CoA thioesterase II -
BZ19_RS01750 402826..403347 + 522 WP_011191872.1 YbaY family lipoprotein -
BZ19_RS01755 403483..403857 - 375 WP_033849400.1 MGMT family protein -
BZ19_RS01760 404827..405030 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
BZ19_RS01765 405079..405447 - 369 WP_033847808.1 Hha toxicity modulator TomB Antitoxin
BZ19_RS01770 405606..405959 - 354 WP_033847806.1 hypothetical protein -
BZ19_RS01775 406833..406976 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
BZ19_RS01780 406992..407252 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T50326 WP_002208622.1 NZ_CP010067:c405030-404827 [Yersinia pseudotuberculosis str. PA3606]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T50326 NZ_CP010067:c405030-404827 [Yersinia pseudotuberculosis str. PA3606]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCACCGTTTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTTTGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT50326 WP_033847808.1 NZ_CP010067:c405447-405079 [Yersinia pseudotuberculosis str. PA3606]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRIFSGEYVCTLMKT

Download         Length: 369 bp

>AT50326 NZ_CP010067:c405447-405079 [Yersinia pseudotuberculosis str. PA3606]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGCAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGAATTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFK3

References