Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 536198..536853 Replicon chromosome
Accession NZ_CP010065
Organism Burkholderia mallei strain 2002721276

Toxin (Protein)


Gene name relE Uniprot ID A0A0H2WL39
Locus tag BO07_RS02540 Protein ID WP_004199884.1
Coordinates 536557..536853 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BO07_RS02535 Protein ID WP_004202809.1
Coordinates 536198..536554 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BO07_RS02505 532330..533088 + 759 WP_004199892.1 cytochrome c1 -
BO07_RS02510 533181..533792 + 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
BO07_RS02515 533862..534383 + 522 WP_004199890.1 ClpXP protease specificity-enhancing factor -
BO07_RS02525 534605..535102 + 498 WP_004199888.1 terminase -
BO07_RS02530 535099..536154 + 1056 WP_004199886.1 phage portal protein -
BO07_RS02535 536198..536554 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BO07_RS02540 536557..536853 - 297 WP_004199884.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BO07_RS02550 537661..538781 + 1121 WP_038802950.1 IS3 family transposase -
BO07_RS02555 538863..540266 - 1404 WP_004524586.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
BO07_RS02560 540604..541023 + 420 WP_004198812.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 534788..551448 16660


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(8-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10840.66 Da        Isoelectric Point: 10.1723

>T50323 WP_004199884.1 NZ_CP010065:c536853-536557 [Burkholderia mallei]
MFKVLTPPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T50323 NZ_CP010065:c536853-536557 [Burkholderia mallei]
ATGTTCAAAGTTCTGACGCCCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT50323 WP_004202809.1 NZ_CP010065:c536554-536198 [Burkholderia mallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT50323 NZ_CP010065:c536554-536198 [Burkholderia mallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2WL39

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References