Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2081225..2081808 Replicon chromosome
Accession NZ_CP010028
Organism Deinococcus swuensis strain DY59

Toxin (Protein)


Gene name mazF Uniprot ID A0A0A7KL74
Locus tag QR90_RS09725 Protein ID WP_039684171.1
Coordinates 2081461..2081808 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0A7KGM6
Locus tag QR90_RS09720 Protein ID WP_039684169.1
Coordinates 2081225..2081467 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QR90_RS09690 2076363..2077325 + 963 WP_039686291.1 IS4 family transposase -
QR90_RS18010 2078168..2078527 + 360 WP_052195598.1 hypothetical protein -
QR90_RS09705 2078667..2079317 - 651 WP_039684164.1 dTMP kinase -
QR90_RS09710 2079321..2080115 - 795 WP_039684166.1 Nif3-like dinuclear metal center hexameric protein -
QR90_RS09715 2080216..2081160 - 945 WP_039684168.1 alpha/beta hydrolase fold domain-containing protein -
QR90_RS09720 2081225..2081467 + 243 WP_039684169.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QR90_RS09725 2081461..2081808 + 348 WP_039684171.1 endoribonuclease MazF Toxin
QR90_RS09730 2081818..2082999 - 1182 WP_039684174.1 acetyl-CoA C-acyltransferase -
QR90_RS09735 2083224..2083676 - 453 WP_039684176.1 helix-turn-helix domain-containing protein -
QR90_RS17250 2083677..2083868 - 192 WP_081995069.1 type II toxin-antitoxin system HicA family toxin -
QR90_RS09740 2083908..2085995 - 2088 WP_052195679.1 enoyl-CoA hydratase/isomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-110)

Antitoxin

Antitoxin PemI-like

(1-80)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12498.35 Da        Isoelectric Point: 8.4867

>T50276 WP_039684171.1 NZ_CP010028:2081461-2081808 [Deinococcus swuensis]
MVGSAYVPERGHLVWLNFTPQAGHEQAGRRPALVLTPASYNAPTGLMIGVPVTSRVKYYPFEVALPGDCAIQGVVLCDQA
RSLDWRSRRADYAGTVSSEILEQVSRKLGTLLQIG

Download         Length: 348 bp

>T50276 NZ_CP010028:2081461-2081808 [Deinococcus swuensis]
ATGGTAGGGAGCGCCTATGTCCCGGAGCGCGGGCATCTGGTCTGGCTCAACTTCACGCCTCAGGCTGGACACGAACAGGC
TGGCAGACGGCCCGCACTGGTGTTGACGCCAGCCTCGTATAACGCGCCCACTGGCCTGATGATCGGTGTGCCCGTGACCA
GTCGGGTCAAGTACTATCCCTTTGAAGTCGCCCTCCCCGGAGACTGCGCCATTCAGGGCGTCGTGTTGTGCGATCAGGCC
CGCAGCCTGGACTGGCGCAGCCGCAGGGCCGACTATGCTGGGACAGTCTCCAGCGAAATTCTGGAACAGGTCAGCCGGAA
ACTCGGCACGCTGCTTCAGATCGGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8911.15 Da        Isoelectric Point: 5.0775

>AT50276 WP_039684169.1 NZ_CP010028:2081225-2081467 [Deinococcus swuensis]
MKGQIQKWGNSLALRIPKRMAEEAGVGQGMPVSVELTEGRIIITPIRATHPTLDELLAQIRPDNLHGEEDWGGPQGREEW

Download         Length: 243 bp

>AT50276 NZ_CP010028:2081225-2081467 [Deinococcus swuensis]
ATGAAAGGACAGATTCAAAAATGGGGCAACAGTCTGGCTTTGCGAATTCCCAAACGGATGGCCGAGGAAGCCGGAGTGGG
ACAGGGCATGCCGGTATCTGTTGAACTGACAGAGGGGCGAATTATCATCACGCCGATCAGGGCCACGCATCCCACCCTGG
ACGAACTTCTGGCACAAATCCGGCCCGACAACCTTCACGGCGAGGAAGACTGGGGCGGGCCGCAGGGCCGTGAGGAATGG
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7KL74

Antitoxin

Source ID Structure
AlphaFold DB A0A0A7KGM6

References