Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1734165..1735958 Replicon chromosome
Accession NZ_CP010027
Organism Paraburkholderia fungorum strain ATCC BAA-463

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag OI25_RS32740 Protein ID WP_046572109.1
Coordinates 1734165..1735064 (+) Length 300 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag OI25_RS32745 Protein ID WP_046572110.1
Coordinates 1735065..1735958 (+) Length 298 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI25_RS32710 1729516..1730592 - 1077 WP_030103722.1 porin -
OI25_RS32715 1731034..1731348 + 315 WP_046572106.1 non-heme iron oxygenase ferredoxin subunit -
OI25_RS32720 1731350..1731661 + 312 WP_028195934.1 hypothetical protein -
OI25_RS32725 1731711..1732808 + 1098 WP_046572107.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
OI25_RS32730 1732801..1733577 + 777 WP_046572108.1 SDR family oxidoreductase -
OI25_RS32735 1733604..1734131 + 528 WP_028195931.1 cupin domain-containing protein -
OI25_RS32740 1734165..1735064 + 900 WP_046572109.1 alpha/beta hydrolase Toxin
OI25_RS32745 1735065..1735958 + 894 WP_046572110.1 IclR family transcriptional regulator Antitoxin
OI25_RS32750 1735955..1736764 + 810 WP_028195928.1 SDR family oxidoreductase -
OI25_RS32755 1736757..1738415 + 1659 WP_046573151.1 thiamine pyrophosphate-binding protein -
OI25_RS32760 1738408..1739238 + 831 WP_028195926.1 aspartate dehydrogenase -
OI25_RS32765 1739271..1740761 + 1491 WP_046572111.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-282)

Antitoxin

Transcription regulator IclR, N-terminal

(32-80)


Sequences

Toxin        


Download         Length: 300 a.a.        Molecular weight: 31557.73 Da        Isoelectric Point: 6.3414

>T50275 WP_046572109.1 NZ_CP010027:1734165-1735064 [Paraburkholderia fungorum]
MSAVPSRIADNVAQNATLEARLARFPAQQIWLASQRAVSYREADSAASDALPLVLLHGIGSGAASWVQQFEMLGETRRVL
AWDAPGYGASTPVEADSPAAGDYATVLKEWLDALGIERCVLLGHSLGAIVAGAFAVTNPQLVAGLLLLSPAGGYGASPAD
VRESKRNQRLAMIKELGPQGLAEKRSTNMLSANASDEARAWVRWNMSRVIPRGYVQATHLLANADLASDLARYKGHISIA
VGADDAITPPEACERLALTASTRLQVVPGAGHAGYIEAPTAYTAIIDTFCRASDGQRSQ

Download         Length: 900 bp

>T50275 NZ_CP010027:1734165-1735064 [Paraburkholderia fungorum]
ATGTCCGCAGTCCCGTCCCGTATCGCCGATAACGTCGCTCAGAACGCCACGCTCGAAGCGCGCCTTGCACGCTTTCCGGC
GCAGCAGATCTGGCTCGCGTCGCAACGTGCGGTGAGTTATCGCGAGGCGGATAGCGCAGCAAGCGACGCACTGCCTTTGG
TGCTGCTTCACGGTATCGGGTCGGGCGCGGCTTCGTGGGTACAACAGTTTGAAATGCTGGGCGAGACGCGCCGTGTGCTG
GCGTGGGATGCGCCGGGATATGGCGCGTCGACCCCGGTAGAAGCCGATTCGCCCGCTGCAGGCGACTACGCAACGGTGCT
GAAAGAATGGCTCGACGCGCTCGGCATTGAGCGCTGTGTGCTGCTGGGGCATTCGCTTGGCGCGATCGTCGCCGGTGCGT
TTGCTGTGACGAATCCGCAGCTTGTGGCCGGTTTACTCCTGCTGTCGCCGGCTGGCGGATATGGCGCTTCGCCTGCGGAC
GTGCGCGAGAGCAAACGCAATCAGCGTCTCGCCATGATTAAGGAACTCGGCCCACAAGGTCTCGCTGAAAAACGCAGCAC
CAATATGTTGTCCGCGAACGCGAGCGATGAAGCGCGCGCATGGGTGCGCTGGAACATGTCGCGGGTGATCCCACGTGGCT
ATGTTCAAGCAACACATCTGCTCGCGAACGCCGATCTCGCCAGCGATCTCGCGCGCTACAAAGGTCACATCAGCATCGCA
GTCGGCGCAGACGACGCTATCACGCCCCCCGAAGCCTGCGAGCGACTCGCCCTGACGGCCAGCACCAGGTTGCAGGTTGT
GCCGGGCGCGGGGCATGCCGGCTATATCGAAGCACCCACCGCGTACACCGCGATCATCGACACGTTCTGCCGCGCGAGCG
ACGGACAACGGAGCCAATGA

Antitoxin


Download         Length: 298 a.a.        Molecular weight: 32988.54 Da        Isoelectric Point: 6.2995

>AT50275 WP_046572110.1 NZ_CP010027:1735065-1735958 [Paraburkholderia fungorum]
MTPDTINAERDADDDRNDADASSEINYRVPGLERGLKILTEFSPREPVLGAPELSKRLKIPRTTVFRLLQTLESLGFLER
ADKDRNYRLGVAVLRLGFEYLSSLELTDLGLPIIEALRNDTGLTSHIVIRDGRDVVFVAKAQSHAPIFSSVKVNVGTRLP
AYATTHGQVLMSDMTLDELKKLYPEPELERFTKQTPATVEELYERVCDDARRGYAISESSFERGISVVSAPVRNDTGRIV
AVITTTIPRPEIDASLLDSGLIDKVRRAADELSQRLNYRPKGSANGGTKYMKALGLK

Download         Length: 894 bp

>AT50275 NZ_CP010027:1735065-1735958 [Paraburkholderia fungorum]
ATGACGCCCGACACGATTAACGCCGAGCGCGACGCGGACGACGACCGCAACGACGCGGACGCCAGCAGCGAGATCAACTA
TCGCGTGCCGGGTCTGGAACGTGGTCTGAAGATACTGACCGAGTTCTCGCCACGCGAGCCGGTTCTCGGCGCACCGGAAC
TATCGAAGCGCCTGAAGATTCCCCGCACAACGGTGTTCCGTCTGCTGCAAACGCTCGAATCGCTCGGTTTTCTCGAGCGC
GCTGATAAGGACCGCAACTATCGCCTCGGCGTCGCGGTGCTTCGGCTCGGTTTCGAGTACCTGAGCTCGCTTGAACTGAC
CGATCTCGGTTTGCCGATCATCGAAGCCTTGCGCAACGACACCGGCCTCACCAGCCATATCGTGATTCGCGACGGACGCG
ATGTTGTGTTCGTCGCCAAGGCGCAAAGTCATGCGCCGATCTTCAGCTCGGTGAAGGTGAACGTCGGTACGCGTCTGCCG
GCTTACGCAACGACGCACGGCCAGGTGCTGATGAGCGACATGACGCTCGACGAGTTGAAAAAGCTCTATCCCGAGCCGGA
ACTGGAACGCTTCACGAAGCAAACACCCGCCACCGTCGAGGAGTTGTACGAACGGGTTTGCGATGACGCGAGGCGCGGTT
ACGCGATCAGCGAATCGTCGTTCGAACGCGGCATTTCCGTGGTGAGCGCGCCGGTTCGCAACGACACGGGCCGTATCGTC
GCGGTGATTACGACCACGATTCCGCGTCCTGAGATCGACGCTTCGCTGCTCGACAGCGGCCTGATCGACAAGGTTCGCCG
CGCGGCCGACGAACTCTCGCAGCGGCTCAATTATCGACCGAAGGGCAGCGCGAACGGTGGCACGAAATACATGAAGGCAC
TGGGACTCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References