Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1859711..1860300 Replicon chromosome
Accession NZ_CP010026
Organism Paraburkholderia fungorum strain ATCC BAA-463

Toxin (Protein)


Gene name hicA Uniprot ID A0A1I7EHY9
Locus tag OI25_RS13420 Protein ID WP_028198502.1
Coordinates 1860118..1860300 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0D5V779
Locus tag OI25_RS13415 Protein ID WP_028198501.1
Coordinates 1859711..1860121 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OI25_RS13400 1856075..1858015 + 1941 WP_046567410.1 flagellar biosynthesis protein FlhF -
OI25_RS13405 1858008..1858877 + 870 WP_028198499.1 P-loop NTPase -
OI25_RS13410 1858906..1859646 + 741 WP_028198500.1 RNA polymerase sigma factor FliA -
OI25_RS13415 1859711..1860121 - 411 WP_028198501.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OI25_RS13420 1860118..1860300 - 183 WP_028198502.1 type II toxin-antitoxin system HicA family toxin Toxin
OI25_RS13425 1860609..1861055 - 447 WP_028198503.1 flagellar protein FlgN -
OI25_RS13430 1861150..1861506 - 357 WP_028198504.1 flagellar biosynthesis anti-sigma factor FlgM -
OI25_RS13435 1861690..1863150 - 1461 WP_052719643.1 flagellar basal body P-ring formation protein FlgA -
OI25_RS13440 1863369..1863863 + 495 WP_028198506.1 flagellar basal body rod protein FlgB -
OI25_RS13445 1864034..1864459 + 426 WP_028198507.1 flagellar basal body rod protein FlgC -
OI25_RS13450 1864470..1865216 + 747 WP_030102375.1 flagellar hook assembly protein FlgD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6569.73 Da        Isoelectric Point: 11.3940

>T50271 WP_028198502.1 NZ_CP010026:c1860300-1860118 [Paraburkholderia fungorum]
MNSAEVVKVIQADGWRLIRISGSHHHFRHAVKAGLVTIPHPKKDLPPGTLNSILKQAGLK

Download         Length: 183 bp

>T50271 NZ_CP010026:c1860300-1860118 [Paraburkholderia fungorum]
ATGAACAGCGCCGAAGTCGTCAAAGTCATTCAAGCGGATGGCTGGCGGTTGATCCGGATATCGGGCAGTCACCATCATTT
TCGTCACGCGGTAAAAGCCGGTCTCGTGACCATCCCGCATCCGAAAAAAGATCTTCCGCCCGGCACATTGAACAGCATCC
TGAAACAGGCGGGTCTGAAATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14824.81 Da        Isoelectric Point: 4.9474

>AT50271 WP_028198501.1 NZ_CP010026:c1860121-1859711 [Paraburkholderia fungorum]
MKNLIFPIAIEPGDTHHAFGVIVPDIPGCHSAGSSLEEAYANAKEAIEAHLDTLLDEGLPIPERLTLEEHRRNPDYAGFT
WGFVTTRNIPALKKAVRINISLPEALVHDIDAYAQARGMSRSAFLALAAEHEMADA

Download         Length: 411 bp

>AT50271 NZ_CP010026:c1860121-1859711 [Paraburkholderia fungorum]
ATGAAAAATCTGATTTTCCCGATCGCAATCGAACCTGGTGACACGCACCACGCGTTCGGCGTGATCGTCCCCGATATTCC
GGGTTGTCATTCGGCGGGTAGTTCGCTGGAAGAAGCCTACGCGAACGCAAAAGAAGCGATCGAGGCGCATCTGGACACGC
TGCTCGATGAAGGCCTGCCGATTCCCGAGCGGCTAACACTGGAGGAACATCGGCGCAATCCCGACTACGCCGGTTTCACC
TGGGGATTTGTCACCACGCGCAATATTCCGGCGCTGAAGAAAGCCGTGCGCATCAATATCTCGCTGCCCGAGGCGCTGGT
TCACGATATCGACGCTTACGCCCAGGCACGCGGCATGTCGCGCTCGGCGTTTCTCGCGCTGGCCGCCGAGCACGAGATGG
CGGATGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I7EHY9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D5V779

References