Detailed information of TA system TA050269

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 452451..453016
• Replicon: chromosome
• Accession: NZ_CP010025
• Organism: Paraburkholderia fungorum strain ATCC BAA-463

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: OI25_RS04460
• Protein ID: WP_046565140.1
• Coordinates: 452645..453016 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A242MMY0
• Locus tag: OI25_RS04455
• Protein ID: WP_046565138.1
• Coordinates: 452451..452648 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OI25_RS04430	447496..447984	+	489	WP_063778805.1	Cu(I)-responsive transcriptional regulator	-
OI25_RS04435	448055..448708	+	654	WP_046565133.1	peroxiredoxin	-
OI25_RS04440	448819..449433	+	615	WP_046565589.1	class I SAM-dependent methyltransferase	-
OI25_RS04445	449583..450740	+	1158	WP_046565136.1	permease	-
OI25_RS04450	451075..452061	-	987	WP_046565137.1	hypothetical protein	-
OI25_RS04455	452451..452648	+	198	WP_046565138.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
OI25_RS04460	452645..453016	+	372	WP_046565140.1	type II toxin-antitoxin system VapC family toxin	Toxin
OI25_RS04465	453055..453687	+	633	WP_046565142.1	hypothetical protein	-
OI25_RS04470	453749..453931	+	183	WP_046565144.1	hypothetical protein	-
OI25_RS04475	454096..455151	+	1056	WP_200898818.1	hypothetical protein	-
OI25_RS42490	455281..456051	+	771	WP_137954097.1	hypothetical protein	-
OI25_RS43110	456090..456266	+	177	WP_158380663.1	hypothetical protein	-
OI25_RS04490	456318..457205	+	888	WP_046565152.1	hypothetical protein	-
OI25_RS04495	457297..457827	+	531	WP_046565154.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-113)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-44)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13648.83 Da
• Isoelectric Point: 4.8728

>T50269 WP_046565140.1 NZ_CP010025:452645-453016 [Paraburkholderia fungorum]
MILVDTSVWIDHINATDPMLTTLLAEERVLAHPYVIGEISLGSLRDRDVVLGALLDLPRAPVATPEETFYLIEREGLFNR
GIGYVDTSLLASARLQPGITIWTRDKRLKKVADELNLGAMLAH

Nucleotide

• Length: 372 bp

>T50269 NZ_CP010025:452645-453016 [Paraburkholderia fungorum]
ATGATTCTTGTCGACACGTCAGTCTGGATTGACCATATCAACGCTACTGATCCTATGCTGACTACTCTCCTTGCCGAGGA
GCGTGTGTTGGCTCATCCATACGTGATAGGTGAGATTTCACTCGGTAGTCTGCGTGACCGTGACGTTGTGCTTGGCGCTT
TGCTCGATTTGCCACGCGCGCCAGTTGCAACACCGGAGGAGACGTTTTATCTGATCGAGCGCGAAGGTCTTTTCAATCGT
GGAATCGGATATGTCGACACGTCACTGTTGGCGTCCGCGCGCCTGCAACCCGGCATCACCATCTGGACGCGTGACAAGCG
TTTGAAGAAAGTTGCGGATGAACTCAATCTCGGCGCGATGCTCGCGCATTAG

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7074.13 Da
• Isoelectric Point: 10.3509

>AT50269 WP_046565138.1 NZ_CP010025:452451-452648 [Paraburkholderia fungorum]
MRTTIALDDDLIAKAQAYTGVEEKTALVREALKALIQREAAKRLANLGGSQPGIKGAPRRRQDVE

Nucleotide

• Length: 198 bp

>AT50269 NZ_CP010025:452451-452648 [Paraburkholderia fungorum]
ATGCGTACGACTATTGCGCTTGATGACGACTTGATCGCCAAGGCTCAAGCCTACACGGGTGTTGAGGAAAAAACGGCCCT
CGTGCGCGAAGCGCTAAAGGCCTTGATCCAGCGTGAAGCCGCGAAACGACTCGCGAATCTTGGCGGTAGCCAACCGGGCA
TCAAAGGGGCACCGCGGCGCCGGCAGGACGTCGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A242MMY0