Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3506983..3507655 Replicon chromosome
Accession NZ_CP010023
Organism Yersinia pestis str. Pestoides B

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag CH60_RS17520 Protein ID WP_002215144.1
Coordinates 3506983..3507408 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag CH60_RS17525 Protein ID WP_002209939.1
Coordinates 3507389..3507655 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH60_RS17500 3502650..3503168 + 519 WP_002209934.1 flavodoxin FldB -
CH60_RS17505 3503258..3504715 - 1458 WP_002220113.1 cell envelope integrity protein CreD -
CH60_RS17510 3504836..3506260 - 1425 WP_002230639.1 two-component system sensor histidine kinase CreC -
CH60_RS17515 3506285..3506983 - 699 WP_002209937.1 two-component system response regulator CreB -
CH60_RS17520 3506983..3507408 - 426 WP_002215144.1 protein YgfX Toxin
CH60_RS17525 3507389..3507655 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
CH60_RS17530 3507972..3508964 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
CH60_RS17535 3509037..3509534 - 498 WP_002209941.1 DUF2165 family protein -
CH60_RS17540 3509792..3510493 - 702 WP_002209942.1 hemolysin III family protein -
CH60_RS17545 3510695..3511798 - 1104 WP_002209943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T50266 WP_002215144.1 NZ_CP010023:c3507408-3506983 [Yersinia pestis str. Pestoides B]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T50266 NZ_CP010023:c3507408-3506983 [Yersinia pestis str. Pestoides B]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT50266 WP_002209939.1 NZ_CP010023:c3507655-3507389 [Yersinia pestis str. Pestoides B]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT50266 NZ_CP010023:c3507655-3507389 [Yersinia pestis str. Pestoides B]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References