Detailed information of TA system TA050264

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 1880101..1881101
• Replicon: chromosome
• Accession: NZ_CP010023
• Organism: Yersinia pestis str. Pestoides B

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: CH60_RS10070
• Protein ID: WP_002210981.1
• Coordinates: 1880643..1881101 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: CH60_RS10065
• Protein ID: WP_002210982.1
• Coordinates: 1880101..1880547 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH60_RS10040	1875265..1876911	-	1647	WP_002210973.1	peptide ABC transporter substrate-binding protein SapA	-
CH60_RS10055	1877583..1878041	+	459	WP_002213759.1	IS200/IS605-like element IS1541A family transposase	-
CH60_RS10060	1878188..1879765	-	1578	WP_002230917.1	transcriptional regulator TyrR	-
CH60_RS10065	1880101..1880547	+	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
CH60_RS10070	1880643..1881101	+	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
CH60_RS10075	1881111..1882172	-	1062	WP_002210980.1	YcjF family protein	-
CH60_RS10080	1882169..1883566	-	1398	WP_002210979.1	YcjX family protein	-
CH60_RS10085	1883547..1883789	-	243	WP_002216375.1	phage shock protein PspD	-
CH60_RS10090	1883874..1884233	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
CH60_RS10095	1884233..1884460	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
CH60_RS10100	1884622..1885287	-	666	WP_002210975.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1877583..1878041	458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T50264 WP_002210981.1 NZ_CP010023:1880643-1881101 [Yersinia pestis str. Pestoides B]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T50264 NZ_CP010023:1880643-1881101 [Yersinia pestis str. Pestoides B]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT50264 WP_002210982.1 NZ_CP010023:1880101-1880547 [Yersinia pestis str. Pestoides B]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT50264 NZ_CP010023:1880101-1880547 [Yersinia pestis str. Pestoides B]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1