Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 897815..898435 Replicon chromosome
Accession NZ_CP010023
Organism Yersinia pestis str. Pestoides B

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag CH60_RS05520 Protein ID WP_002208622.1
Coordinates 898232..898435 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag CH60_RS05515 Protein ID WP_002218472.1
Coordinates 897815..898183 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH60_RS05500 896010..896270 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
CH60_RS05505 896286..896429 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
CH60_RS05510 897303..897656 + 354 WP_002208619.1 hypothetical protein -
CH60_RS05515 897815..898183 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
CH60_RS05520 898232..898435 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
CH60_RS05525 899323..899712 + 390 WP_002208623.1 MGMT family protein -
CH60_RS05530 899848..900369 - 522 WP_002208624.1 lipoprotein -
CH60_RS05535 900626..901486 + 861 WP_002208625.1 acyl-CoA thioesterase II -
CH60_RS05540 901746..903035 - 1290 WP_002228344.1 ammonium transporter AmtB -
CH60_RS05545 903123..903413 - 291 WP_042659203.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T50263 WP_002208622.1 NZ_CP010023:898232-898435 [Yersinia pestis str. Pestoides B]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T50263 NZ_CP010023:898232-898435 [Yersinia pestis str. Pestoides B]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT50263 WP_002218472.1 NZ_CP010023:897815-898183 [Yersinia pestis str. Pestoides B]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT50263 NZ_CP010023:897815-898183 [Yersinia pestis str. Pestoides B]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References