Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 749184..749830 Replicon chromosome
Accession NZ_CP010023
Organism Yersinia pestis str. Pestoides B

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag CH60_RS04790 Protein ID WP_002214976.1
Coordinates 749184..749366 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag CH60_RS04795 Protein ID WP_002211129.1
Coordinates 749411..749830 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH60_RS04755 744570..745040 + 471 WP_002227961.1 flagellar basal body-associated protein FliL -
CH60_RS04760 745046..746047 + 1002 WP_002211135.1 flagellar motor switch protein FliM -
CH60_RS04765 746044..746460 + 417 WP_002211134.1 flagellar motor switch protein FliN -
CH60_RS04770 746460..746996 + 537 WP_002231108.1 flagellar biosynthetic protein FliO -
CH60_RS04775 747077..747817 + 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
CH60_RS04780 747923..748192 + 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
CH60_RS04785 748195..748977 + 783 WP_002211130.1 flagellar type III secretion system protein FliR -
CH60_RS04790 749184..749366 + 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
CH60_RS04795 749411..749830 + 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CH60_RS04800 750088..751047 - 960 WP_002211128.1 sugar kinase -
CH60_RS04805 751096..752118 - 1023 WP_002214974.1 ABC transporter permease -
CH60_RS04810 752121..753698 - 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
CH60_RS04815 753764..754759 - 996 WP_002211125.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T50254 WP_002214976.1 NZ_CP010023:749184-749366 [Yersinia pestis str. Pestoides B]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T50254 NZ_CP010023:749184-749366 [Yersinia pestis str. Pestoides B]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT50254 WP_002211129.1 NZ_CP010023:749411-749830 [Yersinia pestis str. Pestoides B]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT50254 NZ_CP010023:749411-749830 [Yersinia pestis str. Pestoides B]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References