Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 89298..89953 Replicon chromosome
Accession NZ_CP010017
Organism Burkholderia thailandensis 34

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag BTM_RS01870 Protein ID WP_006027262.1
Coordinates 89298..89594 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BTM_RS01875 Protein ID WP_004202809.1
Coordinates 89597..89953 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTM_RS36095 85078..85835 + 758 WP_102889828.1 IS5 family transposase -
BTM_RS01850 86085..86207 + 123 WP_009897078.1 CopG family transcriptional regulator -
BTM_RS01855 86310..86843 + 534 WP_009897076.1 bacteriophage gp29 protein -
BTM_RS01860 86840..87577 + 738 WP_045599088.1 VRR-NUC domain-containing protein -
BTM_RS01865 87592..88707 + 1116 WP_045599089.1 DUF3396 domain-containing protein -
BTM_RS01870 89298..89594 + 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTM_RS01875 89597..89953 + 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BTM_RS01880 89997..90974 - 978 WP_045599090.1 phage portal protein -
BTM_RS01885 91025..91420 - 396 WP_045599091.1 helix-turn-helix domain-containing protein -
BTM_RS01890 91952..92251 + 300 WP_045599092.1 hypothetical protein -
BTM_RS36100 93829..94359 - 531 Protein_88 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 83869..103103 19234


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T50248 WP_006027262.1 NZ_CP010017:89298-89594 [Burkholderia thailandensis 34]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T50248 NZ_CP010017:89298-89594 [Burkholderia thailandensis 34]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT50248 WP_004202809.1 NZ_CP010017:89597-89953 [Burkholderia thailandensis 34]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT50248 NZ_CP010017:89597-89953 [Burkholderia thailandensis 34]
ATGAAAATCAGCGAACTGGCCGAATTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References