50242

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 289114..289750 Replicon chromosome
Accession NZ_CP010014
Organism Bacillus sp. YP1

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag QF06_RS01300 Protein ID WP_003156187.1
Coordinates 289400..289750 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G4NU32
Locus tag QF06_RS01295 Protein ID WP_003225183.1
Coordinates 289114..289395 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QF06_RS01275 285474..286073 - 600 WP_041850724.1 rhomboid family intramembrane serine protease -
QF06_RS01280 286168..286533 + 366 WP_015252768.1 holo-ACP synthase -
QF06_RS01285 286699..287715 + 1017 WP_072557167.1 outer membrane lipoprotein carrier protein LolA -
QF06_RS01290 287829..288998 + 1170 WP_015252766.1 alanine racemase -
QF06_RS01295 289114..289395 + 282 WP_003225183.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
QF06_RS01300 289400..289750 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QF06_RS01305 289865..290689 + 825 WP_009966610.1 RsbT co-antagonist protein RsbRA -
QF06_RS01310 290694..291059 + 366 WP_003225190.1 RsbT antagonist protein RsbS -
QF06_RS01315 291063..291464 + 402 WP_003246640.1 serine/threonine-protein kinase RsbT -
QF06_RS01320 291476..292483 + 1008 WP_003234295.1 phosphoserine phosphatase RsbU -
QF06_RS01325 292545..292874 + 330 WP_003234298.1 anti-sigma factor antagonist RsbV -
QF06_RS01330 292871..293353 + 483 WP_003234299.1 anti-sigma B factor RsbW -
QF06_RS01335 293319..294107 + 789 WP_003246715.1 RNA polymerase sigma factor SigB -
QF06_RS01340 294107..294706 + 600 WP_003246608.1 phosphoserine phosphatase RsbX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T50242 WP_003156187.1 NZ_CP010014:289400-289750 [Bacillus sp. YP1]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

>T50242 NZ_CP010014:289400-289750 [Bacillus sp. YP1]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10546.92 Da        Isoelectric Point: 6.4708

>AT50242 WP_003225183.1 NZ_CP010014:289114-289395 [Bacillus sp. YP1]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG

Download         Length: 282 bp

>AT50242 NZ_CP010014:289114-289395 [Bacillus sp. YP1]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8

Antitoxin

Source ID Structure
AlphaFold DB G4NU32

References