Detailed information of TA system TA050237

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 3616990..3617693
• Replicon: chromosome
• Accession: NZ_CP009997
• Organism: Yersinia kristensenii strain Y231

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: CH54_RS16275
• Protein ID: WP_038630821.1
• Coordinates: 3617328..3617693 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: CH54_RS16270
• Protein ID: WP_038630819.1
• Coordinates: 3616990..3617322 (-)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH54_RS16245	3613060..3614424	+	1365	WP_042562471.1	MFS transporter	-
CH54_RS16250	3614540..3614839	-	300	Protein_3171	DUF4102 domain-containing protein	-
CH54_RS16255	3615240..3615527	-	288	WP_012104592.1	helix-turn-helix transcriptional regulator	-
CH54_RS16260	3615514..3615837	-	324	WP_038630815.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CH54_RS16265	3616037..3616903	-	867	WP_038630817.1	DUF4942 domain-containing protein	-
CH54_RS16270	3616990..3617322	-	333	WP_038630819.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CH54_RS16275	3617328..3617693	-	366	WP_038630821.1	TA system toxin CbtA family protein	Toxin
CH54_RS16280	3617749..3618081	-	333	WP_051957643.1	hypothetical protein	-
CH54_RS16285	3618075..3618548	-	474	WP_038639288.1	DNA repair protein RadC	-
CH54_RS16290	3618581..3619012	-	432	WP_038630823.1	antirestriction protein	-
CH54_RS16295	3619357..3619500	-	144	Protein_3180	homocysteine S-methyltransferase	-
CH54_RS16300	3619582..3619812	-	231	WP_038639291.1	PerC family transcriptional regulator	-
CH54_RS16305	3620822..3621322	+	501	WP_038630827.1	type VI secretion system contractile sheath small subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3594147..3619551	25404

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (11-101)

Antitoxin

• Antitoxin CbeA (9-108)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13396.31 Da
• Isoelectric Point: 6.8773

>T50237 WP_038630821.1 NZ_CP009997:c3617693-3617328 [Yersinia kristensenii]
MKPNPTTAGALPAPAIYQQLLAFLLEHHYGLSLNDTPYHDEQMITQQIEQGISVGDTINTLVEKYALVRIGRTGFSALAQ
DPMLSKGDIVRARQAAGLWRAHFPPTLLYSTESLNPIQPQR

Nucleotide

• Length: 366 bp

>T50237 NZ_CP009997:c3617693-3617328 [Yersinia kristensenii]
ATGAAACCAAACCCCACAACAGCGGGTGCATTACCCGCGCCTGCTATTTATCAACAACTACTCGCTTTCCTGCTGGAGCA
CCACTACGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGATGATTACGCAACAGATTGAACAAGGGATTTCAG
TCGGCGACACCATCAACACACTGGTTGAGAAATATGCCTTAGTGCGTATTGGTCGTACCGGGTTCAGTGCATTGGCACAA
GACCCGATGTTGAGCAAAGGTGATATCGTGCGGGCTCGCCAGGCCGCAGGTCTGTGGCGTGCGCATTTTCCGCCAACGTT
GCTGTACTCAACCGAGTCCCTCAATCCTATTCAACCACAGAGATAG

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12155.83 Da
• Isoelectric Point: 7.0602

>AT50237 WP_038630819.1 NZ_CP009997:c3617322-3616990 [Yersinia kristensenii]
MDNHITTSPTWGLKRDITPRLGARLVQEGTHLHFLSDRAHIVGTFSLEATQALDAAFPTLITKLESQLLSGALDPRRQQG
ITVRHGEFVCEADTLGSHGYLYIAVYQKLA

Nucleotide

• Length: 333 bp

>AT50237 NZ_CP009997:c3617322-3616990 [Yersinia kristensenii]
ATGGATAACCACATTACTACTTCCCCAACATGGGGCCTGAAACGTGATATTACGCCGCGGTTGGGAGCCAGACTGGTGCA
GGAAGGAACACACCTGCACTTTCTGAGCGACAGAGCCCACATTGTCGGCACCTTTTCCCTTGAAGCCACTCAGGCTCTTG
ATGCAGCGTTTCCCACACTGATAACCAAACTGGAATCGCAGTTGCTGTCCGGGGCGCTGGATCCACGCCGTCAGCAAGGC
ATTACCGTTCGGCATGGGGAATTTGTCTGTGAAGCGGATACGCTGGGCAGTCACGGTTACCTCTATATCGCTGTGTATCA
GAAACTGGCTTGA